Dynorphin amide analogs

Details Dynorphin amide analogs Dynorphin amide analogs

1982-06-10

1984-07-31

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

044629419

ABSTRACT:
Dynorphin(1-13) has been previously reported to antagonize the analgesia induced by narcotics in naive hosts. Novel compounds are provided which differ from dynorphin(1-13) by neither potentiating nor antagonizing narcotics, such as morphine, in naive animals. In tolerant hosts the new compounds potentiate narcotic or peptide induced analgesia, and in addition are less susceptible to degradation than dynorphin(1-13).
Particularly preferred of the new compounds are polypeptides having ten amino acids with nitrogen containing moieties at both termini.

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