Dynemicin analogs: synthesis, methods of preparation and use

Details Dynemicin analogs: synthesis, methods of preparation and use Dynemicin analogs: synthesis, methods of preparation and use

1992-09-01

1994-01-25

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

536 168, 536 172, 536 175, 536 176, 536 179, 546 14, 546 34, 546 39, 546 43, C07D49100, A61K 3170, A61K 3144, C07H 1504

Patent

active

052817105

ABSTRACT:
A fused ring system compound is disclosed that contains an epoxide group on one side of the fused rings and an enediyne macrocyclic ring on the other side of the fused rings. The compounds have DNA-cleaving, antimicrobial and tumor growth-inhibiting properties. Chimeric compounds having the fused ring system compound as an aglycone bonded to (i) a sugar moiety as the oligosaccharide portion or (ii) a monoclonal antibody or antibody combining site portion thereof that immunoreacts with target tumor cells are also disclosed. Compositions containing a compound or a chimer are disclosed, as are methods of preparing a compound.

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M
This invention was made with government support under Contract No. CA 46446 awarded by the National Institute of Health. The government has certain rights in the invention.

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