Dynemicin analogs: syntheses, methods of preparation and use

Details Dynemicin analogs: syntheses, methods of preparation and use Dynemicin analogs: syntheses, methods of preparation and use

1994-01-21

1996-06-18

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514279, 546 37, 546 41, 546 47, 549415, A61K 3144, C07D47102, C07D31500

Patent

active

055278051

ABSTRACT:
A fused ring system compound is disclosed that contains an epoxide group on one side of the fused rings and an enediyne macrocyclic ring on the other side of the fused rings. The compounds have DNA-cleaving, antimicrobial and tumor growth-inhibiting properties. Chimeric compounds having the fused ring system compound as an aglycone bonded to (i) a sugar moiety as the oligosaccharide portion or (ii) a monoclonal antibody or antibody combining site portion thereof that immunoreacts with target tumor cells are also disclosed. Compositions containing a compound or a chimer are disclosed, as are methods of preparing a compound.

REFERENCES:
patent: 4079125 (1978-03-01), Sipos
patent: 4349528 (1982-09-01), Koprowski et al.
patent: 4471057 (1984-08-01), Koprowski et al.
patent: 4507391 (1985-03-01), Pukel et al.
patent: 4522918 (1985-06-01), Schlom et al.
patent: 4579827 (1986-04-01), Sakamoto et al.
patent: 4675287 (1987-06-01), Reisfeld et al.
patent: 4837206 (1987-04-01), Golik
Konishi et al, J. Am. Chem. Soc., 112:3715-3716 (1990).
Konishi et al., J. Antibiot., 42:1449-1452 (1989).
Golik et al., J. Am. Chem. Soc., 109:3461-3462 (1987).
Golik et al., J. Am. Chem. Soc., 109:3462-3464 (1987).
Lee et al., J. Am. Chem. Soc., 109:3464-3466 (1987).
Ellestad et al., J. Am. Chem. Soc., :3466-3468 (1987).
Cabel et al., J. Am. Chem. Soc., 112:3253 (1990).
Nicolaou et al, J. Am. Chem. Soc., 110:4866-4868 (1988).
Nicolaou et al., J. Am. Chem. Soc., 110:7247-7248 (1988).
Schoenen et al., Tetrahedron Lett., 30:3765-3768 (1989).
Magnus et al., J. Am. Chem. Soc., 110:6921-6923 (1988).
Kende et al., Tetrahedron Lett., 29:4217-4220 (1988).
Taylor et al., Tetrahedron, 40:457 (1984).
Baker et al., J. Am. Chem. Soc., 111:2700 (1989).
Cheresch et al., Proc. Natl. Acad. Sci., USA, 82:5155-5159 (1985).
Cheresch et al., Proc. Natl. Acad. Sci., USA, 81:5767-5771 (1984).
Cheresch et al. Cancer Res. 44:5112-5118 (1986).
Bumol et al., Proc. Natl. Acad. Sci., USA, 79:1245 (1982).
Harper et al., J. Immunol., 132:2096 (1984).
Cheresch et al., J. Cell. Biol., 102:688 (1986).
Grundler et al., Carbohydr. Res., 135:203 (1985).
Schmidt, Angew. Chem. Int. Ed., Engl., 25:212 (1986).
Mantlo et al., J. Org. Chem., 54:2781 (1989).
Nicolaou et al., J. Am. Chem. Soc., 110:7147 (1989).
Zein et al., Science, 240:1198 (1988).
Konishi et al., J. Antibiotics, XLII:1449 (1989).
Haseltine et al., J. Am. Chem. Soc., 111:7638 (1989).
Banville et al., Can J. Chem., 52:80 (1974).
Savard et al., Tetrahedron, 40:3455 (1984).
Echavarren et al., J. Chem. Res. (3), 364 (1986).
Schmidt et al., Synthesis, 958 (1982).
Masamune et al., J. Org. Chem., 29:681-685 (1964).
Curran et al., J. Org. Chem., 49:2063-2065 (1984).
Boekeltheide et al., J. Am. Chem. Soc., 76:1286-1291 (1954).
Comins et al., J. Org. Chem., 55:292-298 (1990).
Semmelhack et al., Tetrahedron Lett., 31:1521-1522 (1990).
Newcomb et al., J. Am. Chem. Soc., 108, 4132-4134 (1986).
Bergman, Acc. Chem. Res., 6:25-31 (1973).
Jones et al., J. Am. Chem. Soc., 94:660-661 (1972).
Lockhart et al., J. Am. Chem. Soc., 103:4091-4096 (1991).
Darby et al., J. Chem. Soc. Chem. Commun., 1516-1517 (1971).
Wong et al., Tetrahedron Lett., 21:217-220 (1980).
Hazeltine et al., J. Am. Chem. Soc., 111:7638-7640 (1989).
Magnus et al., J. Am. Chem. Soc., 110:1626-1628 (1988).
Magnus et al., J. Am. Chem. Soc., 110:6921-6923 (1988).
Semmelhack et al., Tetrahedron Lett., 32:1521-1522 (1990).
Snyder et al J. Am. Chem. Soc., 111:7630-7632 (1989).
Magnus et al., Tetrahedron Lett., 30:1905-1906 (1989).
Sugiura et al., Proc. Natl. Acad. Sci. USA, 87:3831-3835 (1990).
Dyall et al., J. Am. Chem. Soc., 94:2196 (1972).
Zanarotti, Tetrahedron Lett., 23:3815 (1982).
Zanarotti, J. Org. Chem., 50:941 (1985).
Angle et al., J. Am. Chem. Soc., 111:1136 (1989).
Angle et al., Tetrahedron Lett., 301193 (1989).
Crescenzi et al., Tetrahedron Lett., 31:6095 (1990).
Angle et al., J. Am. Chem. Soc., 112:4524 (1990).
Boldt et al., J. Org. Chem., 52:2146 (1987).
Gaudiano et al., J. Org. Chem., 54:5090 (1989).
Egholm et al., J. Am. Chem. Soc., 111:8291 (1989).
Ramakrishnan et al., J. Med Chem., 29:1215 (1986).
Boldt et al., J. Am. Chem. Soc., 111:2283 (1989).
Gaudiano et al., J. Am. Chem. Soc., 112:9423 (1990).
Karabelas et al., J. Am. Chem. Soc., 112:5372 (1990).
Gaudiano et al., J. Am. Chem. Soc., 112:6704 (1990).
Nicolaou et al., J. Am. Chem. Soc., 112:7416 (1990).
Nicolaou et al., J. Am. Chem. Soc., 113:3106 (1991).
Nicolaou et al., J. Am. Chem. Soc., 112:4085-4086 (1990).
Nicolaou et al., J. Am. Chem. Soc., 112:8193-8195 (1990).
Nicolaou et al., J. Chem. Soc., Chem. Commun., 1275-1277 (1990).
Mukaiyama et al., Chem. Lett., 431 (1981).
Nicolaou et al., J. Am. Chem. Soc., 106:4159 (1984).
David et al., J. Chem. Soc. Perkin Trans 1. 1568 (1979).
Zenhavi et al., J. Org. Chem., 37:2281 (1972).
Zenhavi et al., J. Org. Chem., 37:2281 (1972).
Zenhavi et al., J. Org. Chem., 37:2285 (1972).
Ohtsuka et al., J. Am. Chem. Soc., 100:8210 (1978).
Pillai, Synthesis, 1 (1980).
Paulsen et al., Chem. Ber., 114:3102 (1981).

Affiliated with

Also associated with

Rating

Dynemicin analogs: syntheses, methods of preparation and use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dynemicin analogs: syntheses, methods of preparation and use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dynemicin analogs: syntheses, methods of preparation and use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-223121