Dynemicin analogs

Details Dynemicin analogs Dynemicin analogs

1996-02-08

1998-06-09

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514280, 546 43, A61K 3144, C07D22118, C07D49100, C07D51300

Patent

active

057634513

ABSTRACT:
Non-naturally occuring dynemicin analogs are provided, which are useful as DNA cleaving agents, cytotoxic agents, and/or anti-tumor compounds. Methods of making dynemicin analogs are also provided.

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Yoon, T., et al., "Experiments Directed Toward a Total Synthesis of Dynemicin A: A Solution to the Stereochemical Problem," J. Org. Chem., 59(14):3752-3754 (1994).
Shair, M.D., et al., "A Remarkable Cross Coupling Reaction to Construct the Enediyne Linkage Relevant to Dynemicin A: Synthesis of the Deprotected ABC System," J. Org. Chem., 59(14):3755-3757 (1994).
Myers et al., J. Am. Chem. Soc., 116:11550-11557 (1994).
"Total Synthesis of Dynemicin A Achieved," Chemical & Eng. News, Jan. 23, 1995, p. 22.
Taunton, J., et al., "Total Systheses of Di- and Tri-O-methyl Dynemicin A Methyl Esters," Jm. Am. Chem. Soc., 115(22):10378-10379 (1993).
Porco, J.A., et al., "Transannular Diels-Alder Route to Systems Related to Dynemicin A," J. Am. Chem. Soc., 112:7410-7411 (1990).
Wood, J.L., et al., "Application of the Allylic Diazene Rearrangement: Synthesis of the Enediyne-Bridged Tricyclic Core of Dynemicin A," J. Am. Chem. Soc., 114(14):5898-5900 (1992).
Chikashita, H., et al., "Synthesis of the Angular Anthraquinone Subunit of Dynemicin A," J. Org. Chem., 56(5):1692-1694 (1991).

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