Dynamically formed rotors for lock-in amplifier detection

Details Dynamically formed rotors for lock-in amplifier detection Dynamically formed rotors for lock-in amplifier detection

2005-02-08

2005-02-08

Warden, Jill (Department: 1743)

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is inorganic

C436S043000, C436S063000, C436S501000, C436S510000, C436S518000, C436S523000, C436S524000, C436S525000, C436S536000, C424S009100, C422S050000, C422S052000, C422S051000, C422S051000, C422S068100, C422S081000, C422S082000, C422S082050, C422S082070, C422S082080, C422S105000, C422S105000

Reexamination Certificate

active

06852547

ABSTRACT:
A method for measuring low levels of a substance in a sample includes the formation of a rotor from paramagnetic particles in a substantially uniform magnetic field. The rotor is rotated by rotating the substantially uniform magnetic field. A portion of the substance in a sample is bound to the paramagnetic particles, and a signal having a time-varying component is detected. The signal is then processed using a lock-in amplifier with a reference signal having a frequency twice that of the rotation of the magnetic field. This improves the signal-to-noise ratio of the time-varying component of the signal.

REFERENCES:
patent: 4725140 (1988-02-01), Musha
patent: 5222808 (1993-06-01), Sugarman et al.
patent: 5817458 (1998-10-01), King et al.
patent: 6586259 (2003-07-01), Mahan et al.
patent: 6764859 (2004-07-01), Kreuwel et al.

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