Dynamically controlled crystallization method and apparatus and

Details Dynamically controlled crystallization method and apparatus and Dynamically controlled crystallization method and apparatus and

1998-02-18

1999-10-05

Warden, Sr., Robert J.

Chemical apparatus and process disinfecting, deodorizing, preser

Physical type apparatus

Crystallizer

422253, 422236, 422 62, 117 68, 117201, 117202, 23295, B01D 900, C30B 2300

Patent

active

059619341

ABSTRACT:
A method and apparatus for dynamically controlling the crystallization of proteins including a crystallization chamber or chambers for holding a protein in a salt solution, one or more salt solution chambers, two communication passages respectively coupling the crystallization chamber with each of the salt solution chambers, and transfer mechanisms configured to respectively transfer salt solution between each of the salt solution chambers and the crystallization chamber. The transfer mechanisms are interlocked to maintain the volume of salt solution in the crystallization chamber substantially constant. Salt solution of different concentrations is transferred into and out of the crystallization chamber to adjust the salt concentration in the crystallization chamber to achieve precise control of the crystallization process.

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