Chemistry: analytical and immunological testing – Using activated specie
Patent
1992-08-20
1994-07-26
Warden, Robert J.
Chemistry: analytical and immunological testing
Using activated specie
436 69, G01N 3300, G01N 3700
Patent
active
053326776
ABSTRACT:
A new method of inducing spatiotemporal structures in systems characterized by activation/inhibition kinetics through the action of a differential bulk flow of the key species is disclosed. As Turing predicted, a homogeneous and otherwise stable steady state of a reactive system may lose its stability and form inhomogeneous patterns due to the interaction of diffusion and reaction. This mechanism is believed to form the basis of biological morphogenesis. The Turing instability only arises in systems wherein the diffusion coefficient of the inhibitor is sufficiently greater than that of the activator. The method of the present invention avoids this constraint by using a differential flow between the activation and the inhibition species rather than a differential diffusivity. In one aspect of the invention, this differential flow is achieved by immobilizing one of either the inhibitor or activator species in the flow system containing the other species. The resulting destabilized system, which in this aspect is a BZ reaction, is characterized by travelling waves whose length and propagation velocity are proportional to the flow rate. Technological advantages are disclosed that arise from the operation of a kinetic system under such conditions of differential flow that give rise to the dynamical instability.
REFERENCES:
patent: 4832914 (1989-05-01), Tam et al.
patent: 4968484 (1990-11-01), Nosticzius et al.
patent: 5196126 (1993-03-01), O'Dowd
V. Castets et al., "Experimental Evidence of a Sustained Standing Turing-Type Nonequilibrium Chemical Pattern", Phys. Rev. Lett., 1990, vol. 64, No. 24, pp. 2953-2955.
Q. Ouyang et al., "Transition to Chemical Turbulence", Chaos., 1991, vol. 1, No. 4, pp. 411-420.
H. Meinhardt., Models of Biological Pattern Formation., 1982, Academic Press, Chapter 3, pp. 10-17.
Aguado et al; "Dynamics of Pattern Formation . . . "; Phys. Rev. A. Gen. Phys.; 39(11), 5686-96; 1989. (ABS).
Pearson et al; "Turing Instabilities with Nearly Equal Diffusion Coefficients"; J. Chem. Phys.; 90(3); 1588-99, 1989. (ABS).
Arneodo et al.; "Instabilities at Front Patterns . . . "; Physica; 49(1-2); 141-60, 1991. (ABS).
Li; "Conditions for the Occurrence . . . "; Phys. Lett. A.; 147(4); 204-208; 1990 (ABS).
Malchow; "Spatial Patterning . . . "; Mem. Fac. Sci. Kyoto, Univ. Ser. Biol.; 13(2); 83-100; 1988, Coden: MFKBBJ (ABS).
Belintsev et al; "Model of Pattern Formation . . . "; J. Theor. Biol.; 129(4); 1987, 369-394 (ABS).
Harris et al; "Generation of Spatially Periodic Patterns . . . " J. Embryol Exp. Morphol.; 80(0), 1-20; 1984. (ABS).
Erneux et al; "Turing's Theory in Morphogenesis"; Bull. Math. Biol.; 40(6); 771-790; 1978. (ABS).
Harrison et al., "Kinetically Cooperative Models:Boundary Movement in Optical Resoln., Phase Transitions, and Biological Morphogenesis"; Canadian Journal of Chem; vol. 66 (4), 839-849; 1988.
Hjelmfelt et al; "Chemical Implementation of Neural Networks and Turing Machines"; Proc. Natl. Acad. Sci. USA; vol. 88, pp. 10983-10987, Dec. 1991.
Wheeler et al. "Spatiotemporal Patterns of Expression of NGF and the Low Affinity NGF Receptor in Rat Embryous Suggest Functional Roles in Tissue Morphogenesis and Myogenesis"; Journal of Neuroscience; vol. 12 (3), pp. 930-945, Mar. 1992.
Menzinger Michael
Rovinsky Arkady
Crawford L. M.
Warden Robert J.
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