Dynamic resolution of isoxazoline thioesters to isoxazoline carb

Details Dynamic resolution of isoxazoline thioesters to isoxazoline carb Dynamic resolution of isoxazoline thioesters to isoxazoline carb

1998-03-25

2000-02-08

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548243, 548244, 548245, 548246, C07D26104

Patent

active

060229772

ABSTRACT:
The present invention relates generally to a novel method for preparation of substituted isoxazolin-5-yl acetic acid in high optical purity from a stereoisomeric mixture of an esterified substituted isoxazolin-5-yl acetate. The products are useful in the synthesis of compounds for pharmaceuticals, especially the treatment of thrombolytic disorders, and agricultural products.

REFERENCES:
patent: 4256898 (1981-03-01), Kelly et al.
patent: 4933464 (1990-06-01), Markifsky
patent: 4952700 (1990-08-01), Markofsky et al.
patent: 4970297 (1990-11-01), Castelhano et al.
patent: 5446056 (1995-08-01), Wityak et al.
patent: 5489562 (1996-02-01), Burdge et al.
Stecher et al. Synthesis, (Jan. 1997) pp. 1-16.
Inagaki et al. J. Org. Chem. (1992) 57, pp. 5643-5649.
Dinh et al. (1996) Tetrahedron Letters, vol. 37, No. 42, pp. 7623-7626.
Fulling et al. (1987) J. Am. Chem. Sci., vol. 109, pp. 2845-2846.
Tan et al. (1995) J. Am. Chem. Soc., 117, pp. 9093-9094.
Zhang et al. (1996) Tetrahedron Letters, vol. 37, No. 26, pp. 4455-4458.
Armstrong et al. (1994) Tetrahedron Letters, vol. 35, No. 20, pp. 3239-3242.
Sih et al. (1989) Topics Stereochemistry, 19, pp. 63-125.
Gombos et al. (1989) J. Chem. Soc. Perkin Trans. I, p. 1915-1921.

Affiliated with

Also associated with

Rating

Dynamic resolution of isoxazoline thioesters to isoxazoline carb does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dynamic resolution of isoxazoline thioesters to isoxazoline carb, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dynamic resolution of isoxazoline thioesters to isoxazoline carb will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1682333