Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Patent
1991-07-29
1993-07-13
Warden, Robert J.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
422 8206, 422 8207, 422 8211, 436172, G01N 2164
Patent
active
052271340
ABSTRACT:
An immunochemical sensor for measuring the concentration of immunochemical species in a first solution includes a light-emitting element for exciting fluorescent particles which collide with the surface of the element to cause the particles to, in turn, emit light, where the surface includes first immunoreagents coupled thereto, and a light detector for detecting the light emitted by the particles, where the amount of light detected is dependent upon the elasticity of collision of the particles from the surface of the light-emitting element--more light detected for less elastic collisions. A membrane at least partially surrounds the light-emitting element and includes a second solution which is maintained in contact with the light-emitting element. The membrane allows the passage therethrough of the immunochemical species to be detected while prohibiting passage therethrough of other species. The light-emitting element and membrane are immersed in the first solution to allow measuring the concentration of the immunochemical species. Fluorescent particles are included in the second solution in the membrane and some of the particles have second immunoreagents covalently attached thereto, the second immunoreagents being bindable to the first immunoreagents upon contact therewith. With this configuration, the concentration of immunochemical species comprising either the first or second immunoreagents may be measured by measuring the light intensity of particles colliding with the surface of the light-emitting element which, in turn, provides a measure of the average elasticity of collision of the particles from the surface and this is proportional to the concentration of the immunochemical species to be detected.
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Tran Hien
Warden Robert J.
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