Dyes designed for high sensitivity detection of double-stranded

Details Dyes designed for high sensitivity detection of double-stranded Dyes designed for high sensitivity detection of double-stranded

1996-09-05

1998-07-21

Campbell, Eggerton A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, C07H 2102, C12Q 168

Patent

active

057836876

ABSTRACT:
Novel fluorescent dyes are provided, characterized by having a fluorophore joined to a cationic chain. The dyes are found to provide for high enhancement upon binding to nucleic acid and have strong binding affinities to the nucleic acid, as compared to the fluorophore without the polycationic chain. The dyes find use in detection of dsDNA in gel electrophoresis and solution at substantially higher sensitivities using substantially less dye.

REFERENCES:
patent: 5312921 (1994-05-01), Glazer et al.
patent: 5401847 (1995-03-01), Glazer et al.
patent: 5565554 (1996-10-01), Glazer et al.

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