Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-05-14
1994-05-17
Parr, Margaret
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546109, 546176, 536 2532, 536 266, C07D21538, C07D22112
Patent
active
053129210
ABSTRACT:
Novel fluorescent dyes are provided, characterized by having a fluorophore joined to a polycationic chain of at least two positive charges. The dyes are found to provide for high enhancement upon binding to nucleic acid and have strong binding affinities to the nucleic acid, as compared to the fluorophore without the polycationic chain. The dyes find use in detection of dsDNA in gel electrophoresis and solution at substantially higher sensitivities using substantially less dye.
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Benson Scott C.
Glazer Alexander N.
Campbell Eggerton
Parr Margaret
Regents of the University of California
Rowland Bertram I.
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