Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1996-11-08
1999-10-12
Tsang, Cecilia
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530405, 5303871, 5303891, 5303913, 5303915, 5303919, 530802, 530861, 530866, 4241931, 4241941, 436 91, C07K 1600, A61K 39385
Patent
active
059657138
ABSTRACT:
It is intended to present a sensor capable of labeling with more dyes, applying the labeled protein in immunochromatography making use of antigen-antibody reaction, and having an excellent sensitivity. In a buffer, a protein and a first covalent bonding compound that can react with this protein are reacted to prepare a protein conjugate, then a cyanine labeling dye is added in the buffer containing the protein conjugate, and the protein conjugate and cyanine labeling dye are reacted to prepare a dye labeled protein conjugate. Alternatively, in a buffer solution, a protein and a cyanine labeling dye are reacted to prepare a dye labeled protein, then a first covalent bonding compound that can react with the protein is added in the buffer containing the dye labeled protein, and the dye labeled protein and first covalent bonding protein are reacted to prepare a dye labeled protein conjugate.
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Cytometry, vol. 10, pp. 11-19, 1989.
Chemical Abstract, vol. 126, No. 3, p. 729, Ref. #33025K (JP-08,259,826, Aug. 10, 1996) 1997.
Ratnakar B. Mujumadar, et al., Cyanine Dye Labeling Reagents: Sulfoindoc-yanine Succinimidyl Esters, Bioconjugate Chemistry, vol. 4, No. 2, Mar./Apr. 1993.
Miyazaki Jinsei
Nakayama Hiroshi
Shigeto Nobuyuki
Matsushita Electric - Industrial Co., Ltd.
Mohamed Abdez A.
Tsang Cecilia
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