dUTPase, its isoforms, and diagnostic and other uses

Details dUTPase, its isoforms, and diagnostic and other uses dUTPase, its isoforms, and diagnostic and other uses

1997-03-26

1999-10-05

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 4, 435 18, 435195, 435196, C12Q 142, C12Q 100, C12N 914, C12N 916

Patent

active

059622466

ABSTRACT:
The invention provides the DNA and amino acid sequence of dUTPase, an enzyme which is essential for life and which is increased during periods of cellular proliferation. The human form of the dUTPase enzyme has been found to have two isoforms, a nuclear and a mitochondrial isoform. Methods of determining the proliferation status of a cell, efficacy of antineoplastic compounds, and response to therapy with antineoplastic compounds, using cellular levels of dUTPase is disclosed. A kit containing the necessary reagents for the determination of dUTPase is also disclosed.

REFERENCES:
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