Dual subcoated simulated capsule medicament

Details Dual subcoated simulated capsule medicament Dual subcoated simulated capsule medicament

1990-01-22

1993-03-30

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424454, 424456, 424490, 424492, 424494, 424497, 427 3, A61K 948

Patent

active

051982277

ABSTRACT:
A simulated capsule-like medicament comprising a dual subcoating comprising an initial subcoating of a water soluble film forming polymer, e.g. povidone and a secondary subcoating of a mixture of two soluble film forming polymers, e.g. povidone and hydroxypropyl methylcellulose and a hydrophobic plasticizer, e.g. castor oil, which provides for a smooth uniform and substantially bubble free outer coating, e.g. gelatin, for the capsule-like medicament; and a process of making such medicaments.

REFERENCES:
patent: 599865 (1898-03-01), Richards
patent: 3185626 (1965-05-01), Baker
patent: 3959540 (1976-05-01), Leiberich et al.
patent: 4800087 (1989-01-01), Mehta
patent: 4803079 (1989-02-01), Hsiao et al.
patent: 4820524 (1989-04-01), Berta
patent: 4857337 (1989-08-01), Miller et al.
patent: 4928840 (1990-05-01), Barshay et al.
Pharmaceutical Dosage Forms: Tablets, Hert A. Lieberman, Leon Lachman and Joseph B. Schwartz, pp. 108-113, Second Edition.
Remington's Pharmaceutical Sciences, Eighteenth Edition, p. 1667, Mack Publishing Co., Easton, Pa.

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