Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – X-ray contrast imaging agent
Patent
1995-02-08
1997-09-09
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
X-ray contrast imaging agent
514454, 514457, 549280, 549289, A61K 4904, A01N 4316, C07D31178
Patent
active
056653301
ABSTRACT:
The invention provides a novel compound having the structure ##STR1## wherein R is alkyl and R1, R2, R3 and R4 are each independently OCH3, H or I and n is 0 or 1 and m is 0 or 1.
The compound is useful in a method of treating mammals either therapeutically or imaging mammals for diagnostic purposes. Useful therapeutic areas are in treating lymph nodes and tumors and diagnostic treatment is applicable to lymph nodes, tumors and in blood pool imaging. It is particularly advantageous to link an insoluble carrier molecule with a therapeutic or imaging agent to form the structure above. This makes the conjugate insoluble and thus amenable to forming nanoparticles.
REFERENCES:
patent: 5100914 (1992-03-01), Redenbach-Mueller et al.
patent: 5141734 (1992-08-01), Misra et al.
patent: 5145684 (1992-09-01), Liversidge et al.
Hartley Michael G.
Hollinden Gary E.
Nano Systems LLC
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