Dual mechanism controlled release system for drug dosage forms

Details Dual mechanism controlled release system for drug dosage forms Dual mechanism controlled release system for drug dosage forms

1990-04-06

1992-12-29

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424480, 424481, 424482, 424468, A61K 914

Patent

active

051750031

ABSTRACT:
A dual mechanism polymer mixture composed of pH-sensitive enteric materials and film-forming plasticizers capable of conferring permeability to the enteric material, for use in drug-delivery systems; a matrix pellet composed of a dual mechanism polymer mixture permeated with drug and sometimes covering a pharmaceutically neutral nucleus; a membrane-coated pellet comprising a matrix pellet coated with a dual mechanism polymer mixture envelope of the same or different composition; and a pharmaceutical dosage form containing matrix pellets. The matrix pellet releases acid-soluble drugs by diffusion in acid pH and by disintegration at pH levels of nominally about 5.0 or higher.

REFERENCES:
patent: 3043747 (1962-07-01), Long
patent: 4155993 (1979-05-01), Belleville
patent: 4432966 (1984-02-01), Zeitoun
patent: 4606909 (1986-08-01), Bechgaard
patent: 4704285 (1987-11-01), Alderman
patent: 4772475 (1988-09-01), Fukui
patent: 4775536 (1988-10-01), Patell
patent: 4784858 (1988-11-01), Ventouras
patent: 4786506 (1988-11-01), Fontanelli
patent: 4816264 (1989-03-01), Phillips
patent: 4859471 (1989-08-01), Fulberth
patent: 4919938 (1990-04-01), Lovegrove

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