Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
2000-11-16
2003-07-01
Spear, James M. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C424S400000, C424S043000
Reexamination Certificate
active
06585984
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention concerns a cosmetic product with dual compositions, preferably stored in separate compartments, each composition containing a skin active with at least one of the actives being incompatible in a composition containing the other.
2. The Related Art
A soft, supple and flexible skin has a marked cosmetic appeal. As human skin ages with advancing years, the epidermis can become folded, ridged or furrowed to form wrinkles. These signal loss of youthful appearance and herald the transition to old age. Exposure to excessive doses of sunlight accelerates the transition process. Moreover, the outer layer of the epidermis known as the stratum corneum can become dry and flaky following exposure to cold weather or excessive contact with detergents or solvents.
Science has discovered a few active substances which can counter the aging process. Among these are the retinoids and the alpha-hydroxy carboxylic acids. Unfortunately these active substances can be incompatible under certain conditions. Retinol rapidly degrades in a acidic environment that may be most conducive to the alpha-hydroxys. Combinations of these actives have been reported in U.S. Pat. No. 5,935,589 (Mukhedjee et al.) which places the actives in separate emulsions within a single composition. Retinol is stabilized at a neutral pH in an oil-in-water emulsion. An alpha-hydroxy carboxylic acid such as glycolic acid is dispersed within a water-in-oil emulsion. Both of these emulsions are then carefully combined to form a single cosmetic composition. A problem for such compositions is that over time there will be leakage between the separate emulsions resulting in retinol degradation.
A more direct solution is placement of the different actives into compositions held in separate compartments of a dispenser. Illustrative is U.S. Pat. No. 5,914,116 (Suares et al.) disclosing releasably lockable stackable jars and dual compartment pumps. These packages are designed to deliver the separate actives at different times rather than through simultaneous dosing. In U.S. Pat. No. 5,137,178 (Stokes et al.) a dual compartmented squeezable cosmetic dispenser is disclosed which allows for simultaneous extrusion of separate composition streams.
While each of the aforementioned systems have their particular advantage, they introduce certain disadvantages. Actives placed in dual stream dispensing compartments must be doubly concentrated. Only half of each stream contributes to the final dispensed combined stream concentration. For instance, delivery of 8% alpha-hydroxy carboxylic acid requires a 16% concentrated stream from an equally dispensing dual stream package. High concentration presents problems. Significant skin irritation and erythema may result from localized, non-fully mixed deposition of the stream onto the skin. Internal stability at high concentration may also be compromised. There is need for a better solution.
WO 98/50012 (Noordam et al.) discusses the problem of stabilizing a low pH emulsion of Vitamin C to prevent oxidation of the active. Stabilization is achieved by placing a relatively concentrated aqueous Vitamin C composition in one compartment of a multi-compartment dispensing system. A second compartment contains a cosmetic carrier composition. When ready for use, a small volume of the Vitamin C concentrate is dispensed alongside a larger volume of the carrier base, each being expressed from a separate compartment.
A similar approach has been disclosed by Airspray® in product brochure literature for their Symbio dual-chamber dispenser. Two non-compatible ingredients are separated each from the other until the moment of application. The Symbio package has two separate chambers each connected to its own pump, one of the chambers being smaller and arranged to deliver a concentrate of an unstable cosmetic substance. Among the unstable substances mentioned are Vitamin A (retinol), Vitamin C (ascorbic acid) and Vitamin E (alpha-tocopherol). There is no suggestion that the larger container included any skin actives other than some enzymes and pigmentation control agents. The technology does not present a solution for delivering actives from a dual compartment in a manner that provides nearly identical stored and skin delivered concentrations. Focus is rather upon an active that is stored highly concentrated but delivered dilute.
Accordingly, it is an object of the present invention to provide a cosmetic product that can deliver to the skin a first dermal active agent in a concentration not substantially different from its stored concentration and simultaneously from a separate stream deliver a second dermal active incompatible with the first.
A further object of the present invention is to provide a cosmetic product that delivers an acidic first dermal active to skin at a concentration not substantially different from its stored concentration simultaneously with a second dermal active pH incompatible with the first dermal active.
Still a further object of the present invention is to provide a cosmetic product that delivers a combination of first and second dermal actives from separate compositions in a manner assuring a synergistic skin benefit effect of the combination.
Yet a further object of the present invention is to provide a cosmetic product that delivers a combination of first and second dermal actives from separate compositions in a manner which is relatively non-irritating to the skin.
These and other objects of the present invention will become more readily apparent from consideration of the following summary and detailed description.
SUMMARY OF THE INVENTION
A cosmetic product is provided which includes:
(i) a first cosmetic composition including from about 0.1 to about 20% by weight of said first composition of a first dermal active in a pharmaceutically acceptable carrier, the first dermal active being capable of irritating the skin;
(ii) a second cosmetic composition including from about 0.01 to about 20% by weight of said second composition of a second dermal active incompatible with the first cosmetic composition and delivered in a pharmaceutically acceptable carrier; and
(iii) a dispenser with first and second areas to separately store the respective first and second cosmetic compositions, and wherein the first and second compositions are dispensed to an exit nozzle in a respective dispensing weight ratio of from about 30:1 to about 2:1.
DETAILED DESCRIPTION OF THE INVENTION
Now it has been found that a first dermal active can be delivered to skin at concentrations not much different than its storage concentration and simultaneously be combined with a separately stored second dermal active incompatible with the first. Unequal volumes of the two compositions at the point of use are transferred from a dispenser. The weight ratio of first to second cosmetic composition may range from about 30:1 to about 2:1, preferably from about 15:1 to about 8:1, optimally about 11:1. By this arrangement, the first dermal active is delivered in a concentration not much than about 10 or 20% less than its stored concentration.
Delivery of the compositions of the present invention may be through a dual compartment dispenser. A particularly useful device is sold by Airspray International Inc. under the package trademark of Symbio®. The package has two separate chambers, each connected to its own pump. Both pumps are activated by the same actuator. By depressing the actuator, compositions held in each of the chambers are simultaneously pumped out and mixed in a controlled ratio. One of the chambers is a traditional container connected to its own pump by means of a dip tube. Within that chamber is a smaller one in the form of a cartridge equipped with a plug in the bottom, which moves up during use thus keeping both the cartridge and its contents air-free. Each pump stroke delivers approximately 0.4 grams of product. Per stroke the product delivery ratio between the first outer container and the cartridge is about 11:1.
Pump systems are not the only type of dispenser
Chandar Prem
Hague Jonathan David
Scott Ian Richard
Sulistyowati Endah
Suryo Dwiwahyu Haryo
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