Dual action 2',5'-oligoadenylate antiviral derivatives and uses

Details Dual action 2',5'-oligoadenylate antiviral derivatives and uses Dual action 2',5'-oligoadenylate antiviral derivatives and uses

1994-11-03

1996-08-27

Wilson, James O.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514885, 514889, 514934, 536 252, 536 256, 536 264, A61K 3170, C07H 2100

Patent

active

055501117

ABSTRACT:
Viral infection is inhibited in mammals by administration of metabolically stable, non-toxic 2', 5'-oligoadenylate (2-5A) derivatives that have a dual therapeutic effect. The compounds activate the intracellular latent 2-5A dependent endoribonuclease RNase L and also inhibit the action of viral DNA polymerases. Conjugates of the 2-5A derivatives for therapeutic delivery are also described.

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Suhadolnik et al., The 2-5A System: Molecular and Clinical Aspects of Interferon-Related Pathway, pp. 115-122 (1985).
FEBS Letters, vol. 158, No. 2, "3'-Omethylated analogs of 2-5A as inhibitors of virus replication," Sharma et al., pp. 298-300, (1983).
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