Dual-acting pyrazole antihypertensive agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S236500, C514S256000, C514S341000, C514S364000, C514S381000, C514S406000, C544S124000, C544S333000, C546S275400, C548S131000, C548S250000, C548S373100

Reexamination Certificate

active

07956054

ABSTRACT:
In one aspect, the invention relates to compounds having the formula:wherein: Ar, Z, R3, R4and R5are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

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