Dual-acting antihypertensive agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S396000, C548S300100, C548S311100, C548S262200

Reexamination Certificate

active

08080572

ABSTRACT:
In one aspect, the invention relates to compounds having the formula:wherein: Ar, r, Z, X, R3, and R5-7are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

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