DTPA derivatives modified with non-ester bond and a process for

Details DTPA derivatives modified with non-ester bond and a process for DTPA derivatives modified with non-ester bond and a process for

1996-07-16

1998-07-14

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562565, C07C22900

Patent

active

057806705

ABSTRACT:
Provided are DTPA derivatives having five carbonyl groups, represented by the following formula (1). Further provided is a process for synthesizing a compound (1a) represented by the formula of a compound (1) in which R.sub.2 is 2-alkenyl group (R.sub.4). The process comprises the steps of performing esterification of DTPA, introducing an alkoxycarbonyl group and reacting with 2-alkenyl alkoxyformate in the presence of a palladium catalyst, thereby obtaining the compound (1a). ##STR1##

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Tetrahedron Letters, vol. 37, No. 4, pp. 539-542, 1996, Hisao Nemoto, et al., "A New Synthetic Method of All Carboxylate-Free DTPA Derivatives and its Application to the Synthesis of Gd-Carborane Complex".
1995 International Chemical Congress of Pacific Basin Societies, Dec. 17-22, 1995, Dr. Jianping Cai, et al., "Synthesis of all Carboxylate-Free DTPA Derivatives via Palladium Catalyzed Carbon-Carbon Bond Formation Reaction".

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