dsRNAs for combination therapy in the treatment of viral disease

Details dsRNAs for combination therapy in the treatment of viral disease dsRNAs for combination therapy in the treatment of viral disease

1987-11-25

1990-08-21

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 50, 514120, 514934, A61K 3170

Patent

active

049506528

ABSTRACT:
Studies of Synergistic combinations of dsRNAs and anti-viral agents in the treatment of viral diseases indicates dsRNA, especially mismatched dsRNA, plays a powerful and versatile role as a core drug in combination therapy for human viral pathogens, notably for ARC and AIDS.

REFERENCES:
patent: 4724232 (1988-02-01), Rideout et al.
patent: 4795744 (1989-01-01), Carter
Proc. Ntl. Acad. Sci. U.S.A., Mitsuya et al., vol. 82, pp. 7096-7100, Oct. 1985, "3'-Azido-3'deoxythymidine (BW A509U): An Antiviral Agent that Inhibits . . . ".
Proc. Natl. Acad. Sci. U.S.A., Mitsuya et al., vol. 83, pp. 1914-1915, Mar. 1986, "Inhibition of the in Vitro Infectivity and Cytopathic Effect of Human . . . ".
J. of Biological Response Modifiers, Hubbel et al., 6:525-536, 1987, "Augmented Antitumor Effect of Combined Human Natural Interferon-Alpha . . . ".
Dialog, No. 6160495, 1698-1702, Embase No. 86155555, Chapekar et al., "Potentiation of the Cytocial Effect of Human Immune Interferon . . . ".
Dialog, No. 6109766, pp. 359-365, Embse No. 86104826, Hubbell et al., "Synergistic Antiproliferative Effect of Human Interferons in Combination . . . ".

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