DSP-4 dual specificity phosphatase

Details DSP-4 dual specificity phosphatase DSP-4 dual specificity phosphatase

2005-01-11

2005-01-11

Patterson, Jr., Charles L. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S006120, C435S320100, C435S252300, C536S023200

Reexamination Certificate

active

06841369

ABSTRACT:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-4, and polypeptide variants thereof that stimulate dephosphorylation of DSP-4 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-4 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

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