DSP-2 dual-specificity phosphatase

Details DSP-2 dual-specificity phosphatase DSP-2 dual-specificity phosphatase

2005-02-08

2005-02-08

Slobodyansky, Elizabeth (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S252300, C435S320100, C435S325000, C435S366000, C536S023200

Reexamination Certificate

active

06852520

ABSTRACT:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-2, and polypeptide variants thereof that stimulate dephosphorylation of DSP-2 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-2 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

REFERENCES:
patent: 6165767 (2000-12-01), Lal et al.
patent: WO 9700315 (1997-01-01), None
patent: WO 9706245 (1997-02-01), None
patent: WO 9804712 (1998-02-01), None
patent: WO 9941284 (1999-08-01), None
patent: WO 9949037 (1999-09-01), None
Adams and Cory, “The Bcl-2 Protein Family: Arbiters of Cell Survival,”Science 281(5381):1322-1326, 1998.
Alessi et al., “The Human CL100 Gene Encoded a Tyr/Thr -Protein Phospatase Which Potently and Specifically Inactivates MAP Kinase and Suppresses Its Activation by Oncogenic Ras in Xenopus Oocyte Extracts,”Oncogene 8(7):2015-2020, 1993.
Ashkenazi and Dixit, “Death Receptors: Signaling and Modulation,”Science 281(5381):1305-1308, 1998.
Evan and Littlewood, “A Matter of Life and Cell Death,”Science 281(5381):1317-1322, 1998.
Fauman and Saper, “Structure and Function of the Protein Tyrosine Phosphatases,”TiBS 21(11):413-417, 1996.
Flint et al., “Development of ‘Substrate-Trapping’ Mutants to Identify Physiological Substrates of Protein Tyrosine Phosphatases,”Proc. Natl. Acad. Sci. USA 94:1680-1685, 1997.
Groom et al., “Differential Regulation of the MAP, SAP and RK/p38 Kinases by Pystl, a Novel Cytosolic Dual-Specificity Phosphatase,”The EMBO J. 15(14):3621-3632, 1996.
Guan and Butch, “Isolation and Characterization of a Novel Dual Specific Phosphatase, HVH2, Which Selectively Dephosphorylates the Mitogen-Activated Protein Kinase,”The J. of Biological Chemistry 270(13):7197-7203, 1995.
Jia, “Protein Phosphatases: Structures and Implications,”Biochimie et Biologie Cellulaire 75(1):17-26, 1997.
Keyse, “An Emerging Family of Dual Specificity MAP Kinase Phosphatases,”Biochmica et Biophysica Acta 1265:152-160, 1995.
Keyse and Emslie, “Oxidative Stress and Heat Shock Induce a Human Gene Encoding a Protein-Tyrosine Phosphatase,”Nature 359:644-647, 1992.
Muda et al., “Molecular Cloning and Functional Characterization of a Novel Mitogen-Activated Protein Kinase Phosphatase, MKP-4,”The Journal of Biological Chemistry 272(8):5141-5151, 1997.
Thornberry and Lazebnik, “Caspases: Enemies Within,”Science 281(5381):1312-1316, 1998.
Walton and Dixon, “Protein Tyrosine Phosphatases,”Annu. Rev. Biochem. 62:101-120, 1993.
Ward et al., “Control of MAP Kinase Activation by the Mitogen-Induced Threonine/Tyrosine Phosphatase PAC1,”Nature 367(6464):651-654, 1994.
Zheng and Guan, “Dephosphorylation and Inactivation of the Mitogen-Activated Protein Kinase by a Mitogen-Induced Thr/Tyr Protein Phosphatase,”The J. of Biological Chemistry 268(22):16116-16119, 1993.
GenBank Acc. No. AA356476, Apr. 21, 1997.
GenBank Acc. No. AA527292, Jul. 22, 1997.
GenBank Acc. No. AA915932, Apr. 16, 1998.
GenBank Acc. No. AA926744, May 20, 1998.
GenBank Acc. No. AC004099, Jun. 6, 2000.
GenBank Acc. No. AF038844, Jan. 6, 1999. Xuan et al.
GenBank Acc. No. AI215158, Oct. 21, 1998.
Strausberg (Feb. 2, 1999) Database EST, accession AI215158.*
Strausberg (Jun. 17, 1998) Database EST, accession AA926744.*
Strausberg (Jan. 28, 1999) Database EST, accession AI283262.

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