DSP-12 and DSP-13 dual-specificity phosphatases

Details DSP-12 and DSP-13 dual-specificity phosphatases DSP-12 and DSP-13 dual-specificity phosphatases

2005-06-07

2005-06-07

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S252300, C435S320100, C536S023200, C530S350000

Reexamination Certificate

active

06902919

ABSTRACT:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatases DSP-12 and DSP-13, and polypeptide variants thereof that stimulate dephosphorylation of DSP-12 and DSP-13 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-12 and/or DSP-13 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

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