DSP-10 dual-specificity phosphatase

Details DSP-10 dual-specificity phosphatase DSP-10 dual-specificity phosphatase

2006-05-02

2006-05-02

Monshipouri, Maryam (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C530S350000, C435S252300, C435S320100

Reexamination Certificate

active

07037702

ABSTRACT:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-10, and polypeptide variants thereof that stimulate dephosphorylation of DSP-10 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-10 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.

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