DSCG binding protein and process for preparing same

Details DSCG binding protein and process for preparing same DSCG binding protein and process for preparing same

1986-03-20

1987-07-28

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

424 88, 435 68, 435240, 435241, 530350, 530363, 530387, 530405, 530406, 530409, 530410, 530413, 530809, 530828, C07K 1506, C07K 328

Patent

active

046831355

ABSTRACT:
According to the present invention there is provided an essentially pure protein found in nature in mast cells and in basophiles, which protein is involved in the transfer of calcium into such cells. Such a protein has an isoelectric point of about 3.9 and a MW about 60,000.+-.2,000, and has an amino acid composition as herein defined. There are also provided processes for the preparation of such purified protein. Such protein is of use in blocking histamine release from cells.

REFERENCES:
patent: 4340581 (1982-07-01), Timpl
Chem. Abstracts, vol. 94, 1981, 10835f, Mazurek et al.
Chem. Abstracts, vol. 97, 1982, 122337p, Mazurek et al.
Nature, vol. 286, 1980, pp. 722-723, Mazurek et al.
EMBO Journal, vol. 1, No. 5, Jul. 28, 1982, Mazurek et al, pp. 585-590.

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