Drying process

Details Drying process Drying process

2011-04-19

2011-04-19

Swartz, Rodney P. (Department: 1645)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

C435S260000, C435S307100

Reexamination Certificate

active

07927858

ABSTRACT:
The present invention relates to a method of drying biological and other labile samples so that they can be preserved as a highly viscous liquid. The method involves the steps of preparing a preservation sample by dissolving/suspending an active agent in a solution of a stabilizing agent, subjecting the preservation sample to such temperature and pressure conditions that the preservation sample loses solvent by evaporation without freezing or bubbling to form a foam and removing solvent until the preservation sample dries to form a highly viscous liquid.

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patent: 6306345 (2001-10-01), Bronshtein et al.
Craig et al., “The Relevance of the Amorphous State to Pharmaceutical Dosage Forms: Glassy Drugs and Freeze Dried Systems”.Intl. J. Pharmaceutics, 179(2): 179-207 (1999).
Worrall et al., “Xerovac: An Ulta Rapid Method for the Dehydration and Preservation of Live Attenuated Rinderpest and Peste des Petits Ruminants Vaccines”.Vaccine, 19(7-8):834-839 (2000).
Gribbon et al., Trehalose & Novel hydrophobic sugar glasses drug stabilization and delivery, Chemical Aspects of Drug Delivery Systems, The Royal Society of Chemistry, Cambridge (1996).

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