Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1996-11-05
1999-09-21
Bawa, Raj
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424464, 424465, 424667, 424668, 424499, 424669, A61K 3318
Patent
active
059551011
ABSTRACT:
The present invention is concerned with the use of starch containing amylose as a complexant with iodine for preparing dry powder pharmaceutical formulations useful in the preparation of capsules or tablets. The helical structure of the amylose molecule and its ability to complex. with smaller molecules including iodine make starch (amylose) a desirable vehicle for the administration of iodine (I.sub.2) as a dry powder formulation in capsule or tablet form. These pharmaceutical formulations are particularly useful in the treatment of or the prevention of iodine deficiency diseases including breast dysplasia, breast cancer, endometriosis, premenstrual syndrome and radiation sickness from nuclear fallout.
REFERENCES:
patent: 59756 (1866-01-01), Benedict
patent: 1580400 (1926-04-01), Bommarito
patent: 2022729 (1935-12-01), Malisoff
patent: 2385394 (1945-04-01), Witte
patent: 2816854 (1957-12-01), Gross
patent: 2927058 (1960-03-01), Minto
patent: 3881991 (1975-05-01), Kurimoto et al.
patent: 3888739 (1975-06-01), Whetzel et al.
patent: 4010259 (1977-03-01), Johansson
patent: 4012504 (1977-03-01), Eckols
patent: 4230503 (1980-10-01), Hughes
patent: 4279940 (1981-07-01), Wurzburg et al.
patent: 4384960 (1983-05-01), Polley
patent: 4564521 (1986-01-01), Altadonna
patent: 4729948 (1988-03-01), Saruhashi et al.
patent: 4737459 (1988-04-01), Zeikus et al.
patent: 4744975 (1988-05-01), Suami et al.
patent: 4755397 (1988-07-01), Eden et al.
patent: 4816255 (1989-03-01), Ghent et al.
patent: 4867967 (1989-09-01), Crutcher
patent: 4886661 (1989-12-01), Guy et al.
patent: 5171582 (1992-12-01), Ghent et al.
patent: 5250304 (1993-10-01), Ghent et al.
patent: 5389385 (1995-02-01), Ghent et al.
patent: 5589198 (1996-12-01), Eskin et al.
Bloomer et al., "Estrogen receptor-mediated cytotoxicity using iodine-125" J. Cell. Biochem. (1983) 21:39-45.
Bloomer et al., "Estrogen receptor-mediated cytotoxicity using iodine-125" Chem. Abstracts (1983) 99:(Abstract No. 136212x).
Bloomer et al., "Iodine-125-labelled tamoxifen is differently cytotoxic to cells containing oestrogen receptors" Int. J. Radiat. Biol. (1980) 38(2):197-202.
Bloomer et al., "Iodine-125-labelled tamoxifen is differrently cytotoxic to cells containing oestrogen receptors" Chem. Abstracts (1981) 94:(Abstract No. 94:41160m).
Bluhm et al., "Detailed structure of the V.sub.h -amylose-iodine complex: a linear polyiodine chain" Carbohydrate Research (1981) 89:1-9.
Dyer, "An Index of Tumor Chemotherapy" N.I.H. (1949) pp. 10-12, 22, 23.
Eskin et al., "Replacement therapy with iodine in breast neoplasia" Intl. J. Gynecol. Obstet. (1970) 8(2):232(Abstract No. 354).
Eskin et al., "Etiology of mammary gland pathophysiology induced by iodine deficiency" Frontiers in Thyroidology (1986) G. Medeiros-Neto and E. Gaitan (eds.), Plenum Medical Book Company, New York 2:1027-1031.
Eskin et al., "Human breast uptake of radioactive iodine" Obstetrics and Gynecology (1974) 44(3):398-402.
Eskin., "Iodine and breast cancer--a 1982 update" Biological Trace Element Research (1983) 5:399-412.
Eskin, "Iodine metabolism and breast cancer" Trans. N.Y. Acad. Sci. (1970) 32(8):911-947.
Eskin, "Iodine metabolism and breast cancer" Chem. Abstracts (1971) 75:237(Abstract No. 17655p).
Eskin., "Thyroid hormones and tumor development" Influences of Hormones in Tumor Development (1979) Franklin Publishers, (Chapter 6) pp. 130-156.
Eskin, B.A., "Iodine and mammary cancer" Adv. Exp. Med. Biol. (1978) 91:293-304.
Eskin, B.A., "Iodine and mammary cancer" Chem. Abstracts (1979) 90:337 (Abstracts No. 135752a).
Ghent et al., "Fibrocystic breast dysplasia: A deficiency syndrome" Clin. Invest. Med. (Canada) (1986) 9(3):A66(Abstract No. R-406).
Ghent, "Elemental iodine supplementation in clinical breast dysplasia" Proc. 77th Annual Meeting Amer. Assoc. Cancer Res. (1986) 27:189(Abstract No. 751).
Handa et al., "On the blue color of triiodide ions in starch and starch fractions. II. Characterization of the changes in absorption and circular dichroism spectra triiodide icons in amylose with the DP" Biopolymers (1980) 19:723-740.
Harrison's Principles of Internal Medicine, (1984) Isselbacher et al., (eds.) 13th edition, Part 5: Nutrition, Table 71-4.
Hatch, "Effect of temperature on the starch-iodine spectrophometric calibration line" Anal. Chem. (1982) 54(12):2002-2005.
Hetzel, "Iodine deficiency disorders (IDD) and their eradication" Lancet (1983) 12: 1126-1129.
Honour et al., "Secretion of radioiodine in digestive juices and milk in man" Clin. Science (1952) 11:447-462.
Kelly et al., "Prevalence and geographical distribution of endemic goitre" W.H.O. Monograph, 44: 27-35.
Kemp et al., Organic Chemistry (1980) Worth Publishers, Inc., Chapter 27, pp. 992-994.
Larson et al., "Amperometric method for determining the sorption of iodine by starch" anal. Chem. (1953) 25:802-804.
Martindale, The Extra Pharmacopoeia, 29th Edition, (1989) Reynolds (ed.), The Pharmaceutical Press, London, p. 1185.
Moossa et al., "Thyroid status and breast cancer"Ann. Roy. Coll. Surg. Engl. (1973) 53:178-188.
Pennington, "A review of iodine toxicity reports" Journal of the American Dietetic Association (1990) 90:1571-1581.
Robyt, "In vivo conversion of starch to D-glucose" Starch Chemistry and Technology, pp. 106-108.
Derwent Patent Database Abstract of Russian Patent No. 197385 to Mokhnach (May 31, 1967), 1 page total.
Song et al., "Resistance of the Giarda lamblia cysts to various disinfectants" Chem. Abst. (1984) 101:389-390(Abstract No. 126735r).
Stringer et al., "Comparison of bromine, chlorine & iodine as disinfectants for amoebic cysts" Disinfection--Water & Wastewater (1975), pp. 193-209.
Stringer et al., "Comparison of bromine, chlorine & iodine as disinfectants for amoebic cysts" Chem. Abstracts (1976) 84:299 (Abstract No. 126316k).
Strum et al., "Resting human female breast tissue produces iodinate protein" J. Ultrastructure Res. (1983)84:130-139.
Takeda et al., "Structures and amounts of branched molecules in rice amyloses" Carbohydrate Research (1989) 186:163-166.
Takeda et al., "Structures of indica rice starches (IR48 and IR64) having intermediate affinities for iodine" Carbohydrate Research (1989) 187:287-294.
Takeda et al., "Structures of rice amylopectins with low and high affinities for iodine" Carbohydrate Research (1987) 168:79-88.
U.S. Pharmacopea XVIII (1970) pp. 733-734.
Vishnyakova et al., "On the treatment of dyshormonal hyperplasia of mammary glands" Vestin. Akad. Med. Mawk. U.S.S.R. (1966) 21:26-31.
Yunbing et al., "Clinical observation of 174 cases of hyperplastic cystic disease of breast treated with traditional Chinese medicine" J. Traditional Chinese Medicine (1983) 3(4):291-294.
Eskin Bernard A.
Ghent, deceased William R.
943038 Ontario Inc.
Bawa Raj
LandOfFree
Dry starch-iodine pharmaceutical formulations does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Dry starch-iodine pharmaceutical formulations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dry starch-iodine pharmaceutical formulations will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-77759