Dry mix formulation for bisphosphonic acids

Details Dry mix formulation for bisphosphonic acids Dry mix formulation for bisphosphonic acids

1998-08-28

2000-07-18

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424465, 424494, A61K 920, A61K 914

Patent

active

060904100

ABSTRACT:
Pharmaceutical compositions of bisphosphonic acids, and salts thereof, are prepared by direct compression/dry mix tablet formulation. These pharmaceutical compositions are useful in the treatment of disturbances involving calcium or phosphate metabolism, in particular, the treatment and prevention of diseases involving bone resorption, especially osteoporosis, Paget's disease, malignant hypercalcemia, and metastatic bone disease.

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patent: 5358941 (1994-10-01), Bechard et al.
patent: 5681590 (1997-10-01), Bechard et al.
Lachman et al., The Theory and Practice of Industrial Pharmacy, 3rd edition (1986), p. 326.
Remington's Pharmaceutical Science. 15th Edition, Mack Pub. Co., Easton, PA. pp. 1586-1588.

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