Dry hemostatic compositions and methods for their preparation

Details Dry hemostatic compositions and methods for their preparation Dry hemostatic compositions and methods for their preparation

2001-07-17

2008-10-14

Sheikh, Humera N (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S423000

Reexamination Certificate

active

07435425

ABSTRACT:
Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.

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Hood et al., “Efficacy of topical hemostat Floseal™ matrix in vascular surgery”24th World Congress of the International Society for Cardiovascular Surgery(Sep. 12-16, 1999) 2 pages total.

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