Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Inactivation or attenuation; producing viral subunits
Patent
1996-11-21
1998-11-17
Weber, Jon P.
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
Inactivation or attenuation; producing viral subunits
435 2, A01N 102, C12N 704
Patent
active
058375198
ABSTRACT:
A method of rendering a biologically active protein composition substantially free of viruses is disclosed. The method includes the steps of preparing lyophilized samples of the protein composition having a given moisture content, determining a minimum or threshold moisture content which, when the composition is heated to pasteurizing conditions will result in at least a 3.2 log.sub.10 reduction in virus titer, and then heating the sample under pasteurizing conditions that will result in at least a 3.2 log.sub.10 reduction in virus titer while maintaining biological activity of the protein.
REFERENCES:
patent: 4456590 (1984-06-01), Rubenstein
patent: 4721777 (1988-01-01), Uemura et al.
patent: 4816251 (1989-03-01), Seelich
patent: 4831012 (1989-05-01), Estep
patent: 4876088 (1989-10-01), Hirao et al.
patent: 5614405 (1997-03-01), Eibl et al.
Savage Margaret
Torres Juan
Bayer Corporation
Beck Michael J.
Giblin James A.
Weber Jon P.
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