Dry-heat viral inactivation under controlled moisture conditions

Details Dry-heat viral inactivation under controlled moisture conditions Dry-heat viral inactivation under controlled moisture conditions

1996-11-21

1998-11-17

Weber, Jon P.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

435 2, A01N 102, C12N 704

Patent

active

058375198

ABSTRACT:
A method of rendering a biologically active protein composition substantially free of viruses is disclosed. The method includes the steps of preparing lyophilized samples of the protein composition having a given moisture content, determining a minimum or threshold moisture content which, when the composition is heated to pasteurizing conditions will result in at least a 3.2 log.sub.10 reduction in virus titer, and then heating the sample under pasteurizing conditions that will result in at least a 3.2 log.sub.10 reduction in virus titer while maintaining biological activity of the protein.

REFERENCES:
patent: 4456590 (1984-06-01), Rubenstein
patent: 4721777 (1988-01-01), Uemura et al.
patent: 4816251 (1989-03-01), Seelich
patent: 4831012 (1989-05-01), Estep
patent: 4876088 (1989-10-01), Hirao et al.
patent: 5614405 (1997-03-01), Eibl et al.

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