Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1994-02-28
1996-03-05
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424439, 514778, 514944, A61K 914, A61K 4736
Patent
active
054965632
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a dry gel composition containing a medicine which can be orally administered and capable of forming a gruel-like gel composition upon mixing with a predetermined quantity of water at the time of use.
BACKGROUND OF THE INVENTION
As aged people are increasing in number in the population recently, there is a growing interest in their medical care. The swallowing function in the aged people is generally lower than that of younger healthier people, and it is not easy for them to swallow solid preparations such as tablets and capsules. Thus, it has been usually difficult to administer medicines, which are similar to those to be given to people in the prime of life, to the aged people. In the medical treatment of the aged people, the patients often have two or more diseases to be treated and usually two or more kinds of medicines including the solid preparations are prescribed for them. Thus, the swallowing of the medicines having different shapes often caused much labor and pain for them. It was proposed under these circumstances to administer a liquid preparation such as a syrup instead of the solid capsules in the pharmacotherapy of the aged people. However, the administration must be carefully carried out, since the reflective function in the bifurcation of trachea of the aged people is generally weak, and the liquid might be partially sucked in the trachea at the time of the swallowing. Particularly when an aged patient is nursed at home, serious problems such as dyspnea due to improper suction are often caused.
Therefore, the object of the present invention is to provide a composition from which a preparation which can be easily swallowed by aged people can be prepared at the time of use.
In particular, the object of the present invention is to provide a dry gel composition containing a medicine which can be orally administered and capable of rapidly forming an aqueous gel composition upon mixing with a predetermined quantity of water without heating at the time of use.
DISCLOSURE OF THE INVENTION
After intensive investigations made for the purpose of solving the above-described problems, the inventor has found that a gruel-like composition comprising a gel structure easily causes the swallowing reflex and, therefore, such a composition can be swallowed by even aged people having a weakened swallowing function without causing the improper suction in the trachea. The inventor has also found that the gel composition can be easily prepared from a dry gel composition containing a gelling agent capable of rapidly forming a gel upon mixing with water at 40.degree. C. or below. The present invention has been completed on the basis of these findings.
Namely, the present invention provides a dry gel composition comprising 40% by weight or below, based on the whole composition, of a medicine which can be orally administered, 3% by weight or above of a gelling agent and 5% by weight or below of a binder, which composition is capable of forming an aqueous gruel-like gel composition upon mixing with 2 to 15 parts by weight of water per part by weight of the composition.
In an embodiment of the present invention, the dry gel composition comprises 40% by weight or below of a medicine which can be orally administered, 50% by weight or above of pregelatinized starch and 5% by weight or below of a binder, which composition is capable of forming an aqueous gruel-like gel composition upon mixing with 6 to 8 parts by weight of water per part by weight of the composition.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 shows a hysteresis curve obtained by mixing 1 part by weight of composition 7 given in Table 1 with 8 parts by weight of water, leaving the mixture to stand for 60 min and determining the relationship between shear stress of the aqueous gel composition and the shear rate with a cone plate-type rotational viscometer.
FIG. 2 shows a hysteresis curve obtained by mixing 1 part by weight of composition 6 given in Table 1 with 8 parts by weight of water, leaving the mi
REFERENCES:
patent: 4009268 (1977-02-01), Cardon et al.
patent: 5147655 (1992-09-01), Ibsen
patent: 5262167 (1993-11-01), Vegesna et al.
patent: 5306506 (1994-04-01), Zema et al.
patent: 5374659 (1994-12-01), Gowan, Jr.
Hirai Yasuo
Ito Yoji
Page Thurman K.
Showa Yakuhin Kako Co. Ltd.
Spear James M.
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