Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
1998-11-16
2001-05-29
Wilson, James O. (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S025000, C424S116000, C424S709000, C424S710000
Reexamination Certificate
active
06239115
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a dry flowable for plant disease control containing a polyoxin compound.
2. Related Art
Polyoxin compounds produced by
Streptomyces cacaoi
var. asoensis are nucleoside antibiotics, and they have been known to inhibit growth of pathogenic fungus of plant diseases such as rice sheath blight, pear Alternalia leaf spot, and rice brown spot. Therefore, agricultural chemicals containing the polyoxin compounds as an active ingredient in the form of emulsifiable concentrate and wettable powders have been marketed, and they have been used as fungicide for fruit orchards, tobacco, flowers, turfgrass and the like for the past 30 years or more.
However, the conventional emulsifiable concentrate containing the polyoxin compounds have a drawback that they are unstable as emulsions, and hence suffer from a short effective self-life. Therefore, their use may be limited, and aged emulsions must be discarded. In addition, activity of such conventional emulsifiable concent is not always stable depending on the kind of solvent used, diluted concentration and the like, and therefore they are not always convenient for use.
On the other hand, conventional wettable powders containing the polyoxin compounds also have drawbacks, for example, low content of active ingredient, dusty, unstable friability and dispersibility. Further, because they use clay minerals as a carrier, such clay minerals may adhere to plants to form noticeable taints.
As described above, the conventional formulations containing the polyoxin compounds have various kinds of problems, and there has been a need for developing a novel formulation which overcomes the problems mentioned above.
Meanwhile, environmental pollution due to excessive use of agricultural chemicals has recently become to be paid much attention as a social problem. That is, it is required to prevent as far as possible agricultural chemicals applied to plants or soil from flowing out to neighboring rivers with rainwater and the like to affect on fish occurring in the rivers, to contaminate source for water supply and the like. Therefore, it is desired to provide agricultural chemicals exhibiting excellent activity with a small amount. In particular, such chemicals are highly desirable for golf courses where total amount of agricultural chemicals to be used is limited by regulations.
Further, there are some diseases among those of turfgrass in golf courses and the like for which sufficient activity cannot be obtained unless a locally increased application amount of agricultural chemicals is used. Because the conventional wettable powders do not have sufficient friability, dispersibility and susupensibility, and they have a low content of active ingredients, a lot of water must be used for applying such formulations. Therefore, when such conventional wettable powders are used, greens in golf courses may be drowned and this may make it difficult to play golf. Therefore, there is also a need for developing a formulation requiring less water for application.
An object of the present invention is to solve these problems observed in the prior art. That is, the object of the present invention is to provide a dry flowable containing a polyoxin compound having good friability, dispersibility and suspensibility when mixed with water. Another object of the present invention is to provide a dry flowable capable of efficiently bring out the activity of polyoxin compounds as agricultural chemicals, having a high content of active ingredient, and requiring less amount of water for application.
SUMMARY OF THE INVENTION
In order to achieve the objects mentioned above, the present inventors conducted various studies. As a result, they have found that a dry flowable prepared by mixing a polyoxin compound with a surfactant and a water-soluble inorganic material can efficiently bring out the plant disease control effect of the polyoxin compound, and thus completed the present invention.
Therefore, the present invention provides a dry flowable containing a polyoxin compound, a surfactant and a water-soluble inorganic material.
The dry flowable of the present invention preferably contains at least one polyoxin compound produced by
Streptomyces cacaoi
var. asoensis as the polyoxin compound. The dry flowable of the present invention also preferably contains as the polyoxin compound one or more compounds selected from the group consisting of polyoxin A, polyoxin B, polyoxin D, polyoxin E, polyoxin F, polyoxin G, polyoxin H, polyoxin J, polyoxin K, polyoxin L, polyoxin M, polyoxin N, polyoxin O and salts thereof. Polyoxin B and polyoxin D are preferred among these, and the salts are preferably zinc salts, iron salts or titanium salts. Particularly preferred is zinc salt of polyoxin D. The dry flowable of the present invention preferably contains a polyoxin compound in an amount of 5-30% by weight.
The dry flowable of the present invention preferably contains, as the surfactant, an anionic surfactant such as formalin condensates of sodium naphthalenesulfonate, or a nonionic surfactant such as polyoxyethylene alkyl ethers. As the water-soluble inorganic material, it can contain, for example, sodium sulfate or ammonium sulfate. It is preferred that the dry flowable of the present invention have a particle size in the range of 90-500 &mgr;m, more preferably in the range of 90-355 &mgr;m.
The dry flowable of the present invention can be used for the prevention or the therapy cf, for example, large patch, brown patch, Rhizoctonia patch, Helminthosporium leaf blight, Curvularia leaf blight, and fairy rings of turfgrass, powdery mildew of rose plants and the like. For large patch, brown patch, Rhizoctonia patch, Helminthosporium leaf blight, Curvularia leaf blight, and fairy rings of turfgrass, the dry flowable of the present invention is preferably applied at early stage or before dormant period of these diseases. The dry flowable of the present invention can be mixed with water, and applied to plants or soil.
The dry flowable of the present invention can be produced, for example, by spraying a surfactant into a fluidized bed containing a polyoxin compound and a water-soluble inorganic material, granulating the bed with drying, and selecting particles having a particle size within the range of 90-500 &mgr;m. It can also be produced by granulating a mixture containing a polyoxin compound, a surfactant and a water-soluble inorganic material by manual extrusion through a screen, drying the extruded particles, and selecting particles having a particle size within the range of 90-500 &mgr;m.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
The dry flowable of the present invention will be explained in detail hereinafter.
The dry flowable of the present invention contains a polyoxin compound, a surfactant and a water-soluble inorganic material as essential ingredients.
The polyoxin compound is added to the dryflowable of the present invention as an active ingredient of agricultural chemicals. Preferred examples of the polyoxin compound include, for example, polyoxin A, polyoxin B, polyoxin D, polyoxin E, polyoxin F, polyoxin G, polyoxin H, polyoxin J, polyoxin K, polyoxin L, polyoxin M, polyoxin N, polyoxin O and salts thereof. While the kind of the salts are not particularly limited, preferred are zinc salts, iron salts and titanium salts. These polyoxin compounds may be used alone, or in any combination of two or more kinds of them. Among these, preferred are polyoxinB, polyoxin Dandsalts thereof, and more preferred are polyoxin D and salts thereof. It is particularly preferred to use zinc salt of polyoxin D (Japanese Patent Publication (KOKOKU) No. (Sho) 46-13364/1971). The chemical structures of major polyoxin compounds are mentioned in “THE MERCK INDEX TWELFTH EDITION”, page 1306.
The polyoxin compound used for the dry flowable of the present invention may be either one provided by a fermentation process, or one provided by chemical synthesis. When one obtained by a fermentation process is used, for example, those po
Kochi Shinichiro
Tokumura Jun
Yoshimura Tomoki
Kaken Pharmaceutical Co. Ltd.
Nixon & Vanderhye
Wilson James O.
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