Drugs to improve synaptic transmission

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S269000

Reexamination Certificate

active

07081474

ABSTRACT:
Peripherally administered Brefeldin A and its analogs and derivatives are used to enhance learning and reverse memory dysfunction through induced long term potentiation in hippocampal issues.

REFERENCES:
patent: 5214039 (1993-05-01), Kawaguchi et al.
patent: 5242932 (1993-09-01), Gandy et al.
patent: 3247379 (1984-06-01), None
patent: 4305249 (1994-08-01), None
patent: 0230967 (1987-08-01), None
patent: 57159710 (1982-10-01), None
Boast and Abou-Gharbia, Immune-Directed Mechanisms in Alzheimer's Disease, DN&P, 6(7):564, 1993.
N.R. Carlson, Foundationsl of Physiological Psychology, “Chapter 12: Learning and Memory,” 2nd Edition, Allyn & Bacon: Boston, 1992, pp. 421-430.
Caporaso, et al., Morphologic and Biochemical Analysis of the Intracellular Trafficking of the Alzheimer beta/A4 Amyloid Precursor Protein, Journal of Neuroscience, 14(5 Pt 2):3122, May 1994.
Caporaso, et al., Protein Phosphorylation Regulates the Cellular Trafficking and Processing of the Alzheimer Beta/A4 Amyloid Precursor Protein, Molecular Mechanisms of Membrane Traffic, NATO ASI Series, vol. H74, 1993.
Caporaso, et al., Chloroquine Inhibits Intracellular Degradation But Not Secretion of Alzheimer beta/A4 Amyloid Precursor Protein, Proceedings of the National Academy of Sciences of the U.S., 89(6):2252, Apr. 5, 1992.
Dyrks, et al., Generation of βA4 from the amyloid protein precursor and fragments thereof, FEBS 13297, 335(1):89, 1993.
Carol Ezzell, “Neuroscientists Lay The Groundwork for Détente In the Battle of Learning and Memory Research”, The Jrnl. Of NIH Research, 4:60-64, Nov. 1992.
Gabuzada, D., et al., Inhibition of Energy Metabolism Alters the Processing of Amyloid Precursor Protein and Induces a Potentially Amyloidogenic Derivative, Journal of Biological Chemistry, 269(18):13623-8, May 6, 1994.
Gourmelon, et al., “Action of 1,4-diacid anydrides on m-disubsituted aromatic compounds, (Abstract No. 135556d, XP002035950)”,. Chemical Abstracts 81(21) (Nov. 25, 1974).
Haass, et al., β-Amyloid Peptide and a 3-kDa Fragment are Derived by Distinct Cellular Mechanisms, J. Biol. Chem., 268(5):3021, 1993.
Haass, et al., Normal Cellular Processing of a beta-Amyloid Precursor Protein Results in the Secretion of the Ayloid beta peptide and Related Molecules, Annals of the N.Y. Acad. of Sciences, 695:109-116, Sep. 24, 1993.
Rachel Nowak, “Corners of the Mind: The Cellular Basis of Memory and Learning,” The Jrnl. Of NIH Research, 4:49-55, Jan. 1992.
Nguyen et al., Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP, Science, 265:1104-1107, Aug. 19, 1994.
Rockefeller University, “APP Modulators for the Treatment of Amyloidosis”, Curr. Opin. Ther. Pat., 4/1:77, 1994.
Takashi, et al., “Ascotoxin” (Abstract No. 71697n, XP002045314)., Chemical Abstracts 76(13) (Mar. 27, 1972).

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