Drugs for allergic and eosinophilic diseases

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514485, A01N 4302

Patent

active

057212708

ABSTRACT:
A method of inhibiting human IL-5 gene transcription, mRNA expression and protein production by human T-cells using one or more compounds selected from those shown by formula I shown below (where R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.6 alkyl group) and a therapeutic agent for allergic and eosinophilic inflammatory diseases which contains one or more compounds selected from those shown by the formula. ##STR1##

REFERENCES:
patent: 4843092 (1989-06-01), Shichi et al.
Mori et al., "Allergen-Specific Human T Cell Clones Produce Interleukin-5 upon Stimulation with the Th1 Cytokine Interleukin-2", International Archives of Allergy and Immunology (1995) 107:220-222.
Sheffer, "International Consensus Report on the Diagnosis and Management of Asthma", Clinical and Environmental Allergy Report, May 1992, vol. 22, Supp. 1, pp. 1-72.
Okudaira et al., "Enhanced Production and Gene Expression of IL-5 in Bronchial Asthma", Allergy and Clinical Immunology News (1994) 19-25.
Mori et al., "Regulation of Interleukin-5 Production by Peripheral Blood Mononuclear Cells from Atopic Patients with FK506, Cyclosporin A and Glucocorticoid", International Archives Allergy and Immunology (1994) 104(suppl 1):32-35.
Lopez et al., "Recombinant Human Interleukin 5 is a Selective Activator of Human Eosinophil Function", Journal of Experimental Medicine (1988) 167:219-224.
Egan et al., "Inhibition of Pulmonary Eosinophilia and Hyperactivity by Antibodies to Interleukin-5", International Archives Allergy and Immunology (1995) 107:321-322.
Mori et al., "IL-5 Production CD4+ T Cells of Asthmatic Patients is Suppressed by Glucocorticoids and the Immunosuppressants FK506 and Cyclosporin A", International Immunology (1995) 7(3):449-457.
Mori et al., "Atopic Diseases and Eosinophilic Inflammation-Possible Management with Agents Which Downregulate IL-5 Gene Transcription", Environmental Dermatology (1994) 1:42-54.
Callewaert et al., "Tetranactin, a Macrotetrolide Antibiotic, Suppresses in vitro Proliferation of Human Lymphocytes and Generation of Cytotoxicity", Immunopharmacology (1988) 16:25-32.
Tanouchi et al., "Immunosuppressive Effects of Polynactins (Tetranactin, Trinactin and Dinactin) on Experimental Autoimmune Uveoretinitis in Rats", Jpn. J. Ophthalmol. (1987) 31:218-229.
Tanouchi et al., "Immunosuppressive and Anti-Proliferative Effects of a Macrotetroide Antibiotic Tetranactin", Immunology (1988) 63:471-475.

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