Drugs containing triazaspiro[5.5]undecane derivatives as the...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

active

10472626

ABSTRACT:
A pharmaceutical composition for prevention and/or treatment for HIV infection or AIDS induced by the infection which comprises, as an active ingredient, a triazaspiro[5.5]undecane derivative, a quaternary ammonium salt thereof, an N-oxide thereof, or a non-toxic salt thereof, and if necessary, it may be combined with at least one member of other agents for prevention and/or treatment for HIV infection (wherein all symbols are as defined in the specification.)The triazaspiro[5.5]undecane derivatives, the quaternary ammonium salts thereof or the N-oxides thereof, or the non-toxic salts thereof are useful in preventing and/or treating HIV infection and AIDS induced by the infection.

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Liu et al, “Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection” Cell, vol. 86, pp. 367-377 (1996).
Samson et al, “Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene” Nature, vol. 382, pp. 722-725 (1996).
Maeda, K. et al., “Novel Low Molecular Weight Spirodiketopiperazin Derivatives Potently Inhibit R5HIV-1 Infection through Their Antagonistic Effects on CCR5”, Journal of Biological Chemistry, 276 (37), pp. 35194 to 35200 (2001).

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