Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1994-09-16
1997-05-20
Killos, Paul J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514557, 514960, 514962, 514947, A61K 3119
Patent
active
056312962
ABSTRACT:
Rapid-release S(+)-ibuprofen pellets are proposed whose bioavailability is comparable to that of commercially available racemate formulations. The rapid release of the active substance is promoted by using small amounts of basic inorganic salts, preferably sodium carbonate, or dilute alkali metal hydroxide solutions. Pellets with an active substance content of 90-99% by weight are obtainable in this way. The pellets are suitable for the application of coatings. Pellets with a protective coating can be compressed directly to tablets in this form and with small amounts of suitable tableting adjuncts. The use of the pharmacologically active S(+)-ibuprofen and of the small amounts of adjuncts required makes it possible to prepare compact pharmaceutical forms.
REFERENCES:
patent: 4851444 (1989-07-01), Sunshine et al.
Wechter, W.J. et al Chirality, (1993) 5 (7) 492-4.
Romero A.J. et al, J Pharm. Belg (1993 Jan.-Feb.) 48 (1) 27-32.
Birrenbach Gerd
Juch Rolf-Dieter
Killos Paul J.
Spirig AG, Pharmazeutische Praeparate
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