Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1984-09-14
1988-08-30
Wiseman, Thomas G.
Drug, bio-affecting and body treating compositions
Lymphokine
530387, 530388, 530389, 530390, 530391, 530828, 514 6, 514 8, A61K 3900, C07K 1300
Patent
active
047676213
ABSTRACT:
The present invention relates to drugs characterized in that they comprise, in association, at least one immunotoxin and at least one monovalent carboxylic ionophore.
REFERENCES:
Biswajit Ray et al, Chemical Abstracts, V. 95, No. 36779m, "Enhanced Internalization . . . Ovary Cells".
Biswajit Ray et al, Chemical Abstracts, V. 95, No. 75056t, "Enhancement of Cytotoxicities . . . Nigericin".
Ray et al, Mol Cell Biol, vol. 1(6), pp. 552-559, "Enhancement of Cytotoxicities of Ricin and Pseudomonas Toxin in Chinese Hamster Ovary Cells by Nigericin".
Ray et al, Mol Cell Biol, vol. 1(6), pp. 560-567, "Enhanced Internalization of Ricin in Nigericin-Pretreated Chinese Hamster Ovary Cells".
Alonso et al, FEBS Lett., vol. 127(1), pp. 112-114, 1981, "Permeabilization of Mammalian Cells to Proteins by the Ionophore Nigericin".
Moolten et al, Immunol Rev., vol. 62, pp. 47-73.
Sandvig et al, J Biol Chem, vol. 257, pp. 7504-7513.
Jansen et al, Immunol Rev, vol. 62, pp. 185-216.
Gros Pierre
Jansen Franz
Sanofi
Teskin Robin Lyn
Wiseman Thomas G.
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