Drug units and methods for using same

Details Drug units and methods for using same Drug units and methods for using same

1991-11-12

1993-11-09

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424422, 424426, 424452, 424457, 424458, 424465, 424468, 424470, 424474, 424490, 424 7801, 514925, 514926, 514927, A61K 928, A61K 948

Patent

active

052600718

ABSTRACT:
Medical materials for use in treating maladies in living beings, such as ulcers and other conditions of the digestive tract. In one form, a container is provided for a medication which container also contains an adhesive material which is operatively released from the container or exposed at the surface thereof upon biodegradation or dissolution of a protective coating or wall portion of the container under the effects of fluid in the digestive tract in which the container is exposed, such as by swallowing, to permit such adhesive to temporarily bond and retain the container at a select location in the digestive tract so that it may slowly release its contents thereafter to a select portion of the digestive tract. In another form, a multitude of microcapsules, each containing a small quantity of medication, is mixed with an adhesive material, such as a sucralfate other material which may be swallowed as a tablet or dissolved in a liquid such as water. Such microcapsules are carried with the adhesive material to be bonded temporarily therewith to a select portion of the wall of the digestive tract such that, upon biodegradation or dissolution of the walls of the capsules, the contents thereof may be released over an extended period of time to cooperate with the adhesive material in protecting the lining of the digestive tract from acids secreted by the body, food roughage and the like.

REFERENCES:
patent: 4957741 (1990-09-01), Kamarei et al.
Remingtons Pharmaceutical Sciences, Mack Publishing Co. 18th Edition 1989.

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