Drug therapy for alcohol abusers

Details Drug therapy for alcohol abusers Drug therapy for alcohol abusers

1990-10-01

1992-08-18

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514491, 514811, A61K 3155, A61K 3127

Patent

active

051400324

ABSTRACT:
A novel composition and/or method for the treatment of alcoholism, wherein the composition comprises a therapeutically effective dosage of disulfiram and a drug that affects the neurological system in a manner similar to alcohol, preferably a habit-forming or addictive drug. The method comprises administering a composition to alcoholics that combines therapeutically effective dosages of disulfiram and a habit-forming or addictive drug into a single composition. Preferably, the habit-forming or addictive medication is an anti-anxiety drug and is a member of the benzodiazepine family. Most preferably, the habit-forming, anti-anxiety drug is diazepam.

REFERENCES:
"Engaging the Alcoholic in Treatment and Keeping Him There", Chapter 4, Frederick Baekeland and Lawrence K. Lundwall, pp. 161-195 (1977).
"Lack of interaction between disulfiram and alprazolam in alcoholic patients", Eur J Clin Pharmacol (1990) 38:157-160, B. Diquet et al.
"Interaction of disulfiram with benzodiazepines", Clin. Pharmacol. Ther. Nov. 1978, S. M. MacLeod et al., pp. 583-589.
"A Bahavioral Treatment of Alcoholic Methadone Patients", Ira A. Liebson et al., Annals of Internal Medicine 89:342-344, 1978.
Sellers et al.: New England J Medicine 305(21):1255-1262 1981.
Peachey et al.: Drugs 27(2):171-182 1984.
Kissin: Ann N.Y. Acad Science 252:385-395 1975.
Peachy et al.: Psychiatric Clinics of N. America 7(4):745-756 1984.
Preskorn et al.: Int'l Journal Psychiatry in Medicine 17(2):117-131 1987.
Sellers et al.: Arzneim.-Forsch/Drug Res. 30(I) Nr (5A):882-886 1980.
MacLeod et al.: Clinical Pharmacol. Ther. 24(5):583-589 1978.

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