Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-09-11
2007-09-11
Bunner, Bridget (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S350000, C530S810000
Reexamination Certificate
active
10466313
ABSTRACT:
It has been found that syntaxin binds and regulates the nucleotide binding folds (NBFs) of sulfonylurea receptors (SURs) in a ATP- and ADP-dependent manner. The present invention therefore provides methods for identifying compounds that effect the binding between a syntaxin protein and a NBF1 and/or NBF2 of a sulfonylurea receptor (SUR). Compounds identified using the method of the invention are useful for treating and/or preventing diseases and/or conditions that have, as their underlying basis, a dysregulation of KAT191 channels.
REFERENCES:
Cui et al., H3 domain of syntaxin-1A inhibits Kalp channels by its actions onthe sulfonylurea receptor 1 nucleotide binding folds -1 and -2, 2004, vol. 279, Issue 51, pp. 53259-53265.
Moreau et al., SUR., ABC proteins targeted by KATP channel openers, 2005, vol. 38, pp. 951-963.
Hough et al., Expression, purification, and evidence for the interaction of two nucleotide-binding folds of the sulphonylurea receptor, 2002, Biochemical and Biophysical Research Communications, vol. 294, pp. 191-197.
Janson, L. et al., “KATPChannels and Pancreatic Islet Blood Flow in Anesthetized Rats”, Diabetes, 2003, pp. 2043-2048, vol. 52.
Seino, S., “ATP-Sensitive Potassium Channels: A Model of Heteromultimeric Potassium Channel/Receptor Assemblies”, Annu. Rev. Physiol., 1999, pp. 337-362, vol. 61.
Chutkow, W.A. et al., “Cloning, Tissue Expression, and Chromosomal Localization of SUR2, the Putative Drug-Binding Subunit of Cardiac, Skeletal Muscle, and Vascular KATPChannels”, Diabetes, 1996, pp. 1439-1445, vol. 45.
Lawson, K., “Potassium channel openers as potential therapeutic weapons in ion channel disease”, Kidney International, 2000, pp. 838-845, vol. 57.
Tucker, S.J. et al., “Molecular determinants of KATPchannel inhibition by ATP”, The EMBO Journal, 1998, pp. 3290-3296, vol. 17, No. 12.
Gribble, F. M. et al., The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide, The EMBO Journal, 1997, pp. 1145-1152, vol. 16, No. 8.
Shyng, S-L et al., “Regulation of KATPChannel Activity by Diazoxide and MgADP: Distinct Functions of the Two Nucleotide Binding Folds of the Sulfonylurea Receptor”, J. Gen. Physiol, 1997, pp. 643-654, vol. 110.
Nichols, C.G. et al., “Adenosine diphosphate as an intracellular regulator of insulin secretion”, Science, 1996, pp. 1785-1787, vol. 272.
Ueda, K. et al., “MgADP Antagonism to Mg2+Independent ATP Binding of the Sulfonylurea Receptor SUR1”, The Journal of Biological Chemistry, 1997, pp. 22983-22986, vol. 272, No. 37.
Schwanstecher, M. et al., “Potassium channel openers require ATP to bind to and act through sulfonylurea receptors”, The EMBO Journal, 1998, pp. 5529-5535, vol. 17, No. 19.
Misura, K.M.S. et al., “Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex”, Nature, 2000, pp. 355-362, vol. 404.
Fasshauer, D. et al,, “Conserved Structural Features of the Synaptic Fusion Complex: SNARE Proteins Reclassified as Q-and R-SNAREs” Proceedings of the National Academy of Sciences Untied States of America, 1998, pp. 15781-15786, vol. 95, No. 26.
Naren, A.P. et al., “Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms”, Nature, 1997, pp. 302-305, vol. 390.
Naren, A.P. et al., “Syntaxin 1A Inhibits CFTR Chloride Channels by means of Domain-Specific Protein—Protein Interactions”, Proceedings of the National Academy of Sciences of the United States of America, 1998, pp. 10972-10977, vol. 95, No. 18.
de Tullio, P. et al., “Toward Tissue-Selective Pancreatic B-Cells KATPChannel Openers Belonging to 3-Alkylamino-7-halo-4H-,2,4-benzothiadiazine 1,1-Dioxides”, J. Med. Chem., 2003, pp. 3342-3353, vol. 46.
Carr, R.D. et al., “NN414, a SUR1/Kir6.2-Selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker Rat”, Diabetes, 2003, pp. 2513-2518, vol. 52, No. 10.
Pasyk, E.A. et al., “Syntaxin-1A Binds the Nucleotide-binding Folds of Suphyonylurea Receptor 1 to Regulate the KATPChannel”, 2004, pp. 4234-4240, vol. 279, No. 6.
Higgins, C., “The ABC of Channel Regulation”, Cell, 1995, pp. 693-696, vol. 82.
Sutton, R.B. et al., “Crystal structure of SNARE complex involved in synaptic exocytosis at 2.4 Å resolution”, Nature, 1998, pp. 347-353, vol. 395.
Bereskin & Parr
Bunner Bridget
Dang Ian
Gravelle Micheline
LandOfFree
Drug target within the sulfonylurea receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Drug target within the sulfonylurea receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Drug target within the sulfonylurea receptor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3782989