Drug screening process

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

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435 4, C12Q 102, C12Q 100

Patent

active

059768258

ABSTRACT:
There is disclosed a method for screening drug candidate compounds for anti-epileptic activity, a method for screening drug candidate compounds for activity to prevent or treat symptoms of Alzheimer's disease, and a method for determining cell viability and health of living cells inside polymeric tissue implants.

REFERENCES:
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patent: 5699798 (1997-12-01), Hochman et al.
Barth et al., Optical Imaging of Acute Iscemic Injury in Hippocampal Slice Cultures (Abstract), Society for Neurosciencde, vol. 22, p. 1424, 1996.
Hochman, Intrinsic Optical Changes in Neuronal Tissue, Neurosurgery Clinics of North America, vol. 8, No. 3, p. 393, Jul. 1997.
Hochman et al., Dissociation of Synchronization and Excitability in Furosemide Blockade of Epileptiform Activity, Sciente, vol. 270, p. 99, Oct. 6, 1995.
Echevarria et al., Optical Measurement of Osmotic Water Transport in Cultured Cells, J. Gen. Physiol., vol. 99 p. 573, 1992.
Verkman, Optical Methods to Measure Membrane Transport Processes, J. Membrane Biol., vol. 148, p. 99, 1995.
Nicholson et al., Hindered Diffusion of High Molecular Weight Compounds in Brain Extracellular Microenvironment Measured With Integrative Optical Imaging, Biophysical Journal, vol. 65, p. 2277, 1993.

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