Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1996-07-11
1998-10-13
Sisson, Bradley L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 6, 435 911, 435 912, 514 2, 514 44, 935 76, 935 77, 536 231, 536 2372, 536 2432, C12Q 170, C12Q 168, A01N 3718, C12N 1500
Patent
active
058210504
ABSTRACT:
A method for screening candidate antiviral drugs by monitoring papillomavirus replication in vitro in the presence of candidate drugs is provided.
REFERENCES:
patent: 4921805 (1990-05-01), Gebeyehu et al.
patent: 5601975 (1997-02-01), Bonyhadi et al.
A. M. Del Vecchio et al., "Transient Replication of Human Papillomavirus DNAs," Journal of Virology, vol. 66, No. 10, pp. 5949-5958, Oct. 1992.
W. Brune and M. Durst, "Epithelial Differentiation Fails to Support Replication of Cloned Human Papillomavirus Type 16 DNA in Transfected Keratinocytes," The Journal of Investigative Dermatology, vol. 104, No. 2, pp. 277-281, Feb. 1995.
M. Bossens et al., "In vitro infection of normal human keratinocytes by human papillomavirus type 1 followed by amplification of the viral genome in reconstructed epidermis," Jouranal of General Virology, vol. 73, Part 12, pp. 3269-3273, Dec. 1992.
Bauer et al., "Determinants of Genital Human Papillomavirus Infection in Low-Risk Woment in Portland, Oregon," Sex. Transm. Dis., 1993, 20, 274-278.
Beutner et al., "Epidemiology of Human Papillomavirus Infections," Dermatol. Clin. 1991, 9, 211-218.
Chiang et al., "Viral E1 and E2 Proteins Support Replication of Homologous and Heterologous Papillomaviral Origins," Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 5799-5803.
Chiang et al., "Control of Human Papillomavirus Type 11 Origin of Replication by the E2 Family of Transcription Regulatory Proteins," J. Virol. 1992, 66, 5224-5231.
Cowsert et al., "In Vitro Evaluation of Phosphorthioate Oligonucleotides Targeted to the E2 mRNA of Papillomavirus", Antimicrob. Agents Chemother. 1993, 37, 171-177.
Del Vecchio et al., "Transient Replication of Human Papillomavirus DNAs," J. Virol. 1992, 66, 5949-5958.
Hirt, B., "Selective Extration of Polyoma DNA from Infected Mouse Cell Cultures," J. Mol. Biol. 1967, 26, 365-369.
Schiffman et al., "Epidemiologic Evidence Showing That Human Papillomavirus Infection Causes Most Cervical Intraepithelial Neoplasia," J. Natl. Cancer Inst. 1993, 85, 958964.
Ustav and Stenlund, "Transient Replication of BPV-1 Requires Two Viral Polypeptides Endcoded by the E1 and E2 Open Reading Frames," EMBO J. 1991, 10, 449-457.
Yang et al., "Activation of BPV-1 Replication in vitrro by the Transcription Factor E2," Nature 1991, 353, 628-632.
Clark Paul R.
Cowsert Lex M.
ISIS Pharmaceuticals Inc.
Sisson Bradley L.
LandOfFree
Drug screening assay for antiviral activity against papillomavir does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Drug screening assay for antiviral activity against papillomavir, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Drug screening assay for antiviral activity against papillomavir will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-312137