Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2011-07-26
2011-07-26
Yu, Misook (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Reexamination Certificate
active
07985538
ABSTRACT:
Described herein is a cellular marker, MyD88, useful for assessing an individual's (patient's) sensitivity (or resistance) to chemotherapy, particularly sensitivity (or resistance) to chemotherapeutic drugs, such as plant alkaloids (e.g., a taxane, such as paclitaxel or docetaxel). As described herein, Applicants provide a method by which it is possible to determine whether an individual (cancer cells in an individual) is sensitive to chemotherapy with plant alkaloids (e.g., a taxane, such as paclitaxel or docetaxel). Early identification of chemoresistance in patients with cancer is of utmost importance, particularly since it makes it possible to provide the most appropriate therapy.
REFERENCES:
patent: WO 2005/054814 (2005-06-01), None
patent: WO 2007/042554 (2007-04-01), None
Entrez Gene report (National library of medicine) 2010.
Wang et al Br. J. Haematol, 118:638-45, 2002.
Kavallaris et al JCI. 100:1282-93, 1997.
Abrahams et al J of Immun. 173:4286-96, 2004.
MyD88 search result, 2010.
Bonnert et al, FEBS Lett. 402:81-84, 1997.
Abrahams et al., Toll-like receptors and their role in the trophoblast. Placenta. Aug. 2005;26(7):540-7. Review.
Abrahams et al., Divergent trophoblast responses to bacterial products mediated by TLRs. J Immunol. Oct. 1, 2004;173(7):4286-96.
Abrahams et al., Epithelial ovarian cancer cells secrete functional Fas ligand. Cancer Res. Sep. 1, 2003;63(17):5573-81.
Ackerman et al., Topotecan in cervical cancer. Int J Gynecol Cancer. 2007;17(6):1215-23.
Akira et al., Toll-like receptor signalling. Nat Rev Immunol. Jul. 2004;4(7):499-511. Review.
Akira, Toll-like receptor signaling. J Biol Chem. Oct. 3, 2003;278(40):38105-8. Epub Jul. 30, 2003. Review.
Alvero et al., Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance. Cell Cycle. Jan. 1, 2009;8(1):158-66.
Alvero et al., Molecular mechanism of phenoxodiol-induced apoptosis in ovarian carcinoma cells. Cancer. Feb. 1, 2006;106(3):599-608.
Alvero et al., Telomerase prolongs the lifespan of normal human ovarian surface epithelial cells without inducing neoplastic phenotype. J Soc Gynecol Investig. Dec. 2004;11(8):553-61.
Anderson et al., Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product. Cell. Oct. 1985;42(3):791-8.
Asselin et al., XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. Cancer Res. Mar. 1, 2001;61(5):1862-8.
Balkwill et al., Cancer: an inflammatory link. Nature. Sep. 23, 2004;431(7007):405-6.
Beachy et al., Mending and malignancy. Nature. Sep. 23, 2003;431(7007):402.
Behrens et al., Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues. Cancer Res. Jan. 15, 1987;47(2):414-8.
Bellmunt et al., Clinical activity of vinflunine in transitional cell carcinoma of the urothelium and other solid tumors. Semin Oncol. Jun. 2008;35(3 Suppl 3):S34-43.
Byrd-Leifer et al., The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol. Eur J Immunol. Aug. 2001;31(8):2448-57.
Coussens et al., Inflammation and cancer. Nature. Dec. 19-26, 2002;420(6917):860-7. Review.
Dan et al., Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J Biol Chem. Feb. 13, 2004;279(7):5405-12. Epub Nov. 25, 2003.
Dan et al., Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis. Oncogene. Jan. 22, 2004;23(3):706-15.
De Visser et al., The interplay between innate and adaptive immunity regulates cancer development. Cancer Immunol Immunother. Nov. 2005;54(11):1143-52. Epub May 12, 2005. Review.
Ding et al., Characterization of a method for profiling gene expression in cells recovered from intact human prostate tissue using RNA linear amplification. Prostate Cancer Prostatic Dis. 2006;9(4):379-91. Epub Jun. 20, 2006.
Ding et al., Shared actions of endotoxin and taxol on TNF receptors and TNF release. Science. Apr. 20, 1990;248(4953):370-2.
Flick et al., Apoptosis-based evaluation of chemosensitivity in ovarian cancer patients. J Soc Gynecol Investig. May 2004;11(4):252-9.
Giudice et al., Endometriosis. Lancet. Nov. 13-19, 2004;364(9447):1789-99. Review.
Goto et al., Activation of Toll-like receptors 2, 3, and 4 on human melanoma cells induces inflammatory factors. Mol Cancer Ther. Nov. 2008;7(11):3642-53.
Gutierrez et al., The Fas/Fas-ligand system: a mechanism for immune evasion in human breast carcinomas. Breast Cancer Res Treat. Apr. 1999;54(3):245-53.
Harmey et al., Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion. Int J Cancer. Oct. 10, 2002;101(5):415-22.
Heigener et al., Multicenter randomized open-label phase III study comparing efficacy, safety, and tolerability of conventional carboplatin plus etoposide versus dose-intensified carboplatin plus etoposide plus lenograstim in small-cell lung cancer in “extensive disease” stage. Am J Clin Oncol. Feb. 2009;32(1):61-4.
Holcik et al., XIAP: apoptotic brake and promising therapeutic target. Apoptosis. Aug. 2001;6(4):253-61. Review.
Kamsteeg et al., Phenoxodiol—an isoflavone analog—induces apoptosis in chemoresistant ovarian cancer cells. Oncogene. May 1, 2003;22(17):2611-20.
Kaplan et al., Nonparametric estimation from incomplete observations. J Am Stat Assn. 1958;55:457-81.
Kelly et al., TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer. Cancer Res. Apr. 1, 2006;66(7):3859-68.
Matsuzaki et al., Differential expression of genes in eutopic and ectopic endometrium from patients with ovarian endometriosis. Fertil Steril. Sep. 2006;86(3):548-53. Epub Jul. 3, 2006.
McMillan et al., Systemic inflammatory response predicts survival following curative resection of colorectal cancer. Br J Surg. Feb. 2003;90(2):215-9.
Medzhitov et al., Decoding the patterns of self and nonself by the innate immune system. Science. Apr. 12, 2002;296(5566):298-300.
Medzhitov, Toll-like receptors and innate immunity. Nat Rev Immunol. Nov. 2001;1(2):135-45. Review.
Medzhitov et al., Innate immunity: the virtues of a nonclonal system of recognition. Cell. Oct. 31, 1997;91(3):295-8. Review.
Metzner et al., Evidence of the involvement of phosphatidylinositol 3-kinase in the migration, actin stress fiber formation, and alpha v beta 3-integrin-mediated adherence of human melanoma cells. J Invest Dermatol. Oct. 1996;107(4):597-602.
Nakanishi et al., Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs. Nat Rev Cancer. Apr. 2005;5(4):297-309. Review.
Norgauer et al., Expression and growth-promoting function of the IL-8 receptor beta in human melanoma cells. J Immunol. Feb. 1, 1996;156(3):1132-37.
O'Dwyer et al., Antitumor activity and biochemical effects of aphidicolin glycinate (NSC 303812) alone and in combination with cisplatin in vivo. Cancer Res. Feb. 1, 1994;54(3):724-9.
Pidgeon et al., The role of endotoxin/lipopolysaccharide in surgically induced tumour growth in a murine model of metastatic disease. Br J Cancer. Dec. 1999;81(8):1311-7.
Richmond et al., Growth factor and cytogenetic abnormalities in cultured nevi and malignant melanomas. J Invest Dermatol. Mar. 1986;86(3):295-302.
Richmond et al., Purification of melanoma growth stimulatory activity. J Cell Physiol. Dec. 1986;129(3):375-84.
Riman et al., Review of epidemiological evidence for reproductive and hormonal factors in relation to the risk of epithelial ovarian malignancies. Acta Obstet Gynecol Scand. Sep. 2004;83(9):783-95. Review.
Robinson et al., Soluble mediators of inflammation during tumor development. Adv Cancer Res. 2005;93:159-87. Review.
Sapi et al., Resistance of ovarian carcinoma cells to docetaxel is XIAP dependent and reversible by phenoxodiol. Oncol Res. 2004;14(11-12):567-78.
Schmitz et al., Regulation of death receptor-mediated apoptosis pathways. Int J Bioc
Wolf Greenfield & Sacks P.C.
Yale University
Yao Lei
Yu Misook
LandOfFree
Drug resistance and methods of reversing does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Drug resistance and methods of reversing, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Drug resistance and methods of reversing will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2653512