Drug-releasing system of biodegradable polymer type

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices

Reexamination Certificate

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Reexamination Certificate

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07850993

ABSTRACT:
A method for producing compression-melt molded product using polylactic acid powder is described. The method comprises the steps of: 1) heat-melting polylactic acid having a weight-average molecular weight of 3,000-40,000 at 140-220° C., 2) allowing the melted polylactic acid to cool down to solidify at an ordinary or a lower temperature, 3) pulverizing the solidified polylactic acid at an ordinary temperature into powder, and 4) compressing the powder or a mixture powder prepared by addition of another ingredient, e.g., a biologically active compound, to the carrier powder in a mold at an ordinary temperature to cause the polylactic acid to melt into a molded product of a predetermined shape.

REFERENCES:
patent: 4645664 (1987-02-01), Lange
patent: 5248700 (1993-09-01), Lance
patent: 57-97526 (1983-12-01), None
patent: 2-120710 (1992-12-01), None
Trypsin Complex Ointment disclosure. Downloaded from the world wide web on Aug. 30, 2007.
“Preparation and in vivo Characteristics of Biodegradable Copoly-(DL-alanine/ β-ethyl L-aspartate) Formlations with Various Structures of Drug Dispersion”, Asano et al. Yakuzaigaku, Vol. 49, No. 2 (1989) 116-126.

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