Drug release controlling material responsive to changes in tempe

Details Drug release controlling material responsive to changes in tempe Drug release controlling material responsive to changes in tempe

1994-11-09

1995-05-23

Nagumo, Mark

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424486, 424473, 424426, 424489, 424451, 424409, 424405, 524559, 525450, 525921, 525937, 5262924, 526298, 526320, 526321, 528354, A61K 900

Patent

active

054179831

ABSTRACT:
The present invention related to a drug release controlling material responsive to changes in temperature comprising the polyester gel which is obtained by polymerization of a polyfunctional macromonomer represented by the general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms, X.sup.1 represents a hydrogen atom, a halogen atom, a cyano group, an alkyl group having from 1 to 6 carbon atoms or a phenyl group, A represents an aliphatic polyester chain, m is 0 or 1, and p, which may be the same or different in each branched chain, represents an integer of from 0 to 6, optionally with a polyethylene glycol derivative which contains polymerizable group(s) at the end(s). The drug release controlling material has an on-off control function of drug release responsive to changes in temperature depending upon the gel transition of the aliphatic polyester gel.

REFERENCES:
patent: 3700643 (1972-10-01), Smith et al.
patent: 4540809 (1985-09-01), Yokoshima et al.
patent: 4632975 (1986-12-01), Cornell et al.
patent: 4692336 (1987-09-01), Eckenhoff et al.
patent: 5053228 (1991-10-01), Mori et al.
patent: 5139790 (1992-08-01), Snipes
patent: 5330768 (1994-07-01), Park et al.
Die Makromolekulare Chemie, vol. 188, No. 10, pp. 2267-2275, Oct. 1987, Y. Gnanou, et al., "Synthesis of Poly(.epsilon.-Caprolactone) Macromonomers".

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