Drug release controlling coating material for long acting formul

Details Drug release controlling coating material for long acting formul Drug release controlling coating material for long acting formul

1992-05-18

1993-11-02

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424457, 424468, 424487, 424462, 514356, A61K 916

Patent

active

052581861

ABSTRACT:
A coating material for controlling drug release, useful for long acting formulations--e.g. for once-a-day administration, and to a long acting granular composition comprising a drug (especially one conventionally difficult to prepare in long acting form) coated with the coating material. This composition may be mixed with other granular drug formulations. The drug-release controlling coating material comprising, in a specific ratio, one specific water-insoluble and low water-permeability polymers and two materials differing from each other in the pH-dependency of their solubility (pH-dependent polymer-materials).

REFERENCES:
patent: 4758437 (1988-07-01), Sonobe
patent: 4765988 (1988-08-01), Sonobe
patent: 4772475 (1988-09-01), Fukui
patent: 4777033 (1988-10-01), Ikura
patent: 4940556 (1990-07-01), MacFarlane
patent: 4963365 (1990-10-01), Samejima

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