Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-03-26
1990-04-17
Rollins, John W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514822, 514833, 514866, 514884, A61K 3135
Patent
active
049180991
ABSTRACT:
A novel drug comprises as active ingredient an extract extractable from plant material of plants belonging to the genus Caesalpinia, one or several components of this extract and/or one or several substances present in this extract or derived therefrom but prepared synthetically.
These substances are in particular benz(b)indeno(2.1-d)pyran derivatives, including brazilin, brazilein, hematoxylin and/or hematein. The drug is especially suited for treatment of a patient suffering from micro-circulatory disorders, diabetes mellitus, increased blood sugar values, increasing blood platelet aggregation, increased blood viscosity, decreased eryhtrocyte deformability, disorders of the lysosomal enzyme activity and/or suffering from disorders of the prostaglandin metabolism, especially increasing thromboxane A.sub.2 activity.
REFERENCES:
patent: 4147691 (1979-04-01), Montgomery et al.
patent: 4363669 (1982-12-01), Cottrell et al.
patent: 4569839 (1986-02-01), Grollier et al.
Planta Med 66-7 (1985) "Inhibition of Lens-Aldoes Reductase Activity by Brazilin and Hematoxylin".
Planta Med 31 214-20 (1977) Anti-inflammatory Principles of Caesalpinia and Haematoxylan.
Steinmetz, Codex Vegetabilis, 1957, No. 212-216.
Lewis, Medical Botany, 1977, pp. 245 and 375.
The Dispensatory of the U.S.A., 23rd Ed. 1943, Brazil-wood, pp. 1290-1291.
Merck Index, Nos. 1380, 4493 & 4496, 1976.
Altschul, Drugs and Foods from Little-Known Plants, 1973, Nos. 1709-1716.
Chem. Absts. 102: 130972d, 1985.
Moon et al, Planta Med. 66-7 (1985).
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