Drug-polymer conjugates coupled to a peptidic carrier

Details Drug-polymer conjugates coupled to a peptidic carrier Drug-polymer conjugates coupled to a peptidic carrier

2006-02-16

2010-12-07

Tsang, Cecilia (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S016700, C514S018700, C530S300000, C530S329000, C530S331000, C424S404000

Reexamination Certificate

active

07846893

ABSTRACT:
Monodisperse macromolecular conjugate compositions of a peptidic carrier irreversibly or reversibly conjugated with one or more effectors and one or more therapeutic agents, wherein at least one effector or therapeutic agent is attached to a pendant reactive group on said peptidic carrier via a water-soluble polymer. Monodispersity is obtained through the use of orthogonal and separate conjugation reactions.

REFERENCES:
patent: 2003/0091640 (2003-05-01), Ramanathan et al.
Pooyan, 2002, Bioconjugate Chemistry, 13, 216-223.
Law, Journal of pharmaceutical sciences, (Aug. 2001) vol. 90, No. 8, pp. 1015-1025.
Duncan, R., “Drug-Polymer Conjugates: Potential for Improved Chemotherapy”, Anti-Cancer Drug, Jun. 1992, vol. 3. pp. 175-210.
Hallbrink, M., “Cargo Delivery Kinetics of Cell-Penetrating Peptides”, Biochimica et Biophysica Acta, Dec. 2001, vol. 1515. pp. 101-109.

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